Mark Sloan and Izzie Steves

In a still shot from "Losing My Mind," from the fourth season of Grey's Anatomy, Izzie and Mark have a serious conversation in the halls of Seattle Grace.
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Isobel and Mark

In a still shot from "Losing My Mind," from the fourth season of Grey's Anatomy, Mark and Izzie have a serious conversation at Seattle Grace.
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Bizarre Love Triangle?

Maybe, and not quite the way you think! Callie Torres, Erica Hahn and Mark Sloan have a conversation in "The Becoming."
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Callie Torres and Mark Sloan

Callie Torres and Mark Sloan made some love in the on-call room. But surprisingly, Mark later gave her the cold shoulder.
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Crazy Callie

In this scene from "The Becoming," from Grey's Anatomy Season Four, Callie Torres (Sara Ramirez) is looking a little forlorn and unsure of what to do.
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Passed Over

In this scene from "The Becoming," Erica Hahn reacts to having lost out on an award to Preston Burke. That guy continues to get the best of her even though he's not even on the show anymore!
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All Together Now

In this scene from "The Becoming," from Grey's Anatomy Season Four, our favorite group of interns / residents are all together. What are they looking at?
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An Expression of Concern From Derek

In this scene from "The Becoming," from Grey's Anatomy Season Four, Derek is a bit worried as he prepares for the difficult operation he knows is to come.
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Mer and Der at Work

In this scene from "The Becoming," from Grey's Anatomy Season Four, Meredith and Derek practice on a fake brain before delving into the real one later on.
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She Got Game

In this scene from "The Becoming," from Grey's Anatomy Season Four, Meredith is preparing for an surgery in her clinical trial with Derek. Girl's got skills!
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Pay Attention to Me!

In this scene from "The Becoming," from Grey's Anatomy Season 4, Meredith is preparing for an operation in her clinical trial with Derek. But she's really thinking about the brain surgeon she's working with.
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Jello?

In this scene from "The Becoming," Meredith and Derek practice on a fake brain as they prepare for an operation in their clinical trial with Derek. Cool... and gross.
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Grey's Anatomy Season 4 Quotes

Everyday is my mothers birthday. My mother was born in March. He lied. He's a liar. And I'm glad. Really, I'm glad that you found him charming. I'm sure he was delightful. He's a blast after five drinks, not so much after nine though; he gets a little weepy and mean. He's a drunk, Meredith. He probably came in and told you how wonderful you are. How sad he is he doesn't get to spend more time with you. You know, yesterday he told me I was his favorite daughter. The day before, I was an ungrateful bitch. The week before, he wrote me a check for $20,000 because he said I deserved everything life had to offer, because he was so proud of me, a lifetime's worth of proud. So thank you for letting me know that I need to keep a better eye on him. Thanks.

Lexie

Meredith: I will take the ER and your interns.
Cristina: Are you sure?
Meredith: Take the surgery. Makes you feel better and you start to regain strength. [leaves]
Alex: I saw the whole thing, Yang. You can stop pretending.
Cristina: Oh I'm not pretending. I'm sad. I'm very sad. Me so sad!
Alex: Yes, you tried.
Cristina: Hey, forget it. Sad is mine. Go, find your own pretend-emotion.