Penny: Honey, have you ever run before?
Sheldon: Certainly. I've run from bullies, dogs, angry chickens and one particularly persistent PE teacher determined to bend me over and give me a scoliosis test.

Penny: What's the matter?
Sheldon [confused by Leonard having Leslie in his room]: I don't know what the protocol is here. Do I stay? Do I leave? Do I wait to greet them with a refreshing beverage?
Penny: Gee, Sheldon, you're asking the wrong girl. I'm usually on the other side of the tie.

Today's the day a girl's finally going to touch you in your little special place.

Leonard: So, I've got a gunshot wound. That's pretty bad-ass.
Penny: No, you've got a Reebok with a gunshot wound and an ouchie on your pinky toe.

Penny: Sheldon, what do you want?
Sheldon: I'm certain this will come as no surprise to you, but Leonard is failing in yet another relationship.
Penny: He's having problems with Stephanie?
Sheldon: She's sending virtual livestock to random men on the Internet

Sheldon: So, you're saying that friendship contains within it an inherent obligation to maintain confidences?
Penny: Well, yeah.
Sheldon: Interesting. One more question—and perhaps I should have led with this—when did we become friends?

I'm from Nebraska. When we shoot things, it's because we want to eat em' or make them leave our boyfriends alone

Penny: Who's Adam West?
Sheldon: Who's Adam West!? Leonard, what do you talk about after the coitus?
Wolowitz: My guess is "four minutes, a new record!"

Sheldon: Can't we just go to Big Boy? They only have one burger: the Big Boy.
Penny: The Barbecue Burger is like the Big Boy.
Sheldon: Excuse me, in a world that already includes a Big Boy, why would I settle for something that's like a Big Boy?

Sheldon: In Texas, when a cow stops giving milk, they don't continue feeding her. They take her out and shoot her between the eyes.
Penny: I'm confused. Did Sheldon stop giving milk?

Leonard: If my PE teachers told me this is what I was training for I would have tried a lot harder.
Penny: Do or do not, there is no try.
Leonard: Did you just quote Star Wars?
Penny: I believe I quoted Empire Strikes Back.
Leonard: Oh my God. I'm lying in bed with a beautiful woman who can quote Yoda.

Bernadette: Doesn't he know you have a boyfriend?
Penny: Oh, she doesn't have a boyfriend; she has a Sheldon.

TBBT Quotes

Oh, Bernadette, please play my clarinet.

Raj's poem

Sheldon: I'll have a diet Coke.
Penny: Can you please order a cocktail? I need to practice mixing drinks.
Sheldon: Fine... I'll have a virgin Cuba Libre.
Penny: That's... rum and Coke without the rum.
Sheldon: Yes, and would you make it diet?