Leonard: No, just you and me.
Penny: Have you thought this through?
Leonard: Yes, and I think we should go anyway.

Penny: Sheldon, what do you want?
Sheldon: I'm certain this will come as no surprise to you, but Leonard is failing in yet another relationship.
Penny: He's having problems with Stephanie?
Sheldon: She's sending virtual livestock to random men on the Internet

Leonard: So, I've got a gunshot wound. That's pretty bad-ass.
Penny: No, you've got a Reebok with a gunshot wound and an ouchie on your pinky toe.

Bernadette: Well, what if Hulk picked up Thor while Thor is holding the hammer.
Amy: Yeah?
Bernadette: Then by the transitive property of picking things up Hulk picked up the hammer.
Amy: No. Hulk picked up Thor. Thor picked up the hammer.
Penny: Okay, hang on. If I go to a bar and pick up a guy and he picks up a girl and then we all leave together. Did I pick up the girl?
Amy: Did that ever happen?
Penny: Hey, are we talking about me or are we talking about Thor?

Penny: "Want of Understanding"? What does that even mean?
Amy: Ding, ding, ding. We have a winner.

Sheldon: Anyway, the housekeeper in the faculty residence didn't speak any English. When I finaly managed to convince her I was sick, she said, "Möchtest du eine Darmspülung?"
Penny: What does that mean?
Sheldon: Based on what happened next, I assume it means, "Would you like an enema?"

Wolowitz: Over the years, we've formulated a number of theories about how he might reproduce. I'm an advocate of mitosis.
Penny: I'm sorry?
Wolowitz: I believe one day Sheldon will eat an enormous amount of Thai food and split into two Sheldons.
Leonard: On the other hand, I think Sheldon might be the larval form of his species and someday he'll spin a cocoon and emerge two months later with moth wings and an exoskeleton

Okay, so future grief-stricken widow is the one to beat.

I feel like two totally different people. Dr. Jekyyl and Mrs. Whore.

Leonard: We think we can help you with your stage fright.
Sheldon: Oh, I doubt that. I haven't figured out a way, and I'm much smarter than all of you.
Penny: Yes, buy you're not smaller than all of us put together.
Sheldon: I'm sorry, that is what I meant.

Howard: I got pretty exciting NASA news today. Next week I fly to Houston for orientation and zero-gravity elimination drills.
Penny: What does that mean?
Bernadette: He's gonna to learn to poop in space.
Howard: Open the pod bay doors, HAL.
Raj: Maybe your nickname should be "Brown Dynamite."

Penny: So, you know, isn't there maybe some way you and Sheldon could compromise on this whole presentation thing?
Leonard: No. Scientists do not compromise. Our minds are trained to synthesize facts and come to inarguable conclusions. Not to mention Sheldon is bat-crap crazy

TBBT Quotes

Sheldon [to Kripke]: Also, I am given to understand that your mother is overweight.
Raj: Oh, snap.
Sheldon: Now of course, if that is the result of a glandular condition and not sloth and gluttony then I withdraw that comment.

How is "doable" anything but a compliment?

Wolowitz