Dean: Where am I going?
Sam: Dean, it's Valentine Day. Your favorite holiday, remember? I mean, what do you always call it - uh, Unattached Drifter Christmas?

Dean: Well... this is it.
Sam: This is what?
Dean: Team Free Will. One ex-blood junkie, one dropout with six bucks to his name, and Mr. Comatose over there. It's awesome.
Sam: It's not funny.
Dean: I'm not laughing.

Dean: What exactly are we gonna march up there and tell 'em?
Sam: Uh, the truth.
Dean: What, that their sons are back from the future to save them from an angel gone Terminator? Come on, those movies haven't even come out yet.

Dean: Really? Anna?
Castiel: It's true.
Dean: So she's gone all Glenn Close, huh? That's awesome.
Castiel: Who's Glenn Close?
Dean: No one. Just this psycho bitch who likes to boil rabbits.
Sam: So, the... the plan to kill me--would it actually stop Satan?
Dean: No, Sam, come on.
Sam: Cass, what do you think? Does Anna have a point?
Castiel: No. She's a... "Glenn Close."

Sam: You still crazy?
Dean: Not any more than usual.

Sam: Okay, last words?
Dean: I think I'm good.
Sam: Yeah, me too.
Dean: Here goes nothing.

Sam: Oh, hey, Chuck, look. If you really want to publish more books, I guess that's okay with us.
Chuck: Wow. Really?
Sam: No, not really. We have guns and we will find you.

Dr. Piccolo: Doctor, seriously.
Sam: What?
Dr. Picolo: Seriously, you are brilliant, you know that, and a coward. You're a brilliant coward.
Sam: Uh, what are you talking about?
Dr. Picolo: As if you don't know.

Trickster/Gabriel: Where'd I screw up.
Sam: You didn't. Nobody gets the jump on Castiel like you did.
Dean: Mostly it was the way you talked about Armageddon.
Trickster/Gabriel: Meaning?
Dean: Well, call it personal experience. Nobody gets that angry unless they're talking about their own family.
Sam: So which one are you? Grumpy, Sleepy, or Douchy?

I am doing all I can, to slightly lessen the spread of... of genital herpes. And that's a good thing.

Sam: It was you on the police scanner, right? This is a trick.
Trickster: Hello? Trickster.

Cathy Randolph: I could have sworn I saw... the Incredible Hulk.
Sam: The Incredible Hulk?
Cathy Randolph: I told you, it's crazy.
Dean: Bana or Norton?
Cathy Randolph: Oh, no, those movies were terrible. The TV Hulk.
Dean: Lou Ferrigno?
Cathy Randolph: Yes.

Supernatural Quotes

You betrayed me? No one in the history of torture's been tortured with torture like the torture you'll be tortured with.

Crowley

Hey, you leave my baby alone! She's got nothing to do with this!

Dean