Sam: Wait. That anatomy dummy you were molesting at the lab.
Dean: Excuse me?
Sam: What if that's what this is about?
Dean: What exactly are you accusing me of?

Dean: Be my valentine?
Sam: Dude, we're working. Put it back.
Dean: Have a heart.

Sam: So, Mel Gibson really took a turn this past year, huh?
Dean: Or he's possessed. Seriously. Think about it.

Dean: One of Dad's rules? You never use the same crapper twice.
Sam: Everyone uses the same crapper twice.
Dean: Not us. You know what I mean.

Samuel: You think there are maybe calmer ways we could have done all that?
Sam: Do we care?

Sam: What language is it in?
Bobby: Da Vinci Code.

Sam: Why don't you cut to the chase and just roll in it?
Dean: I rarely have wealth.

Sam: What kind of thing likes virgins and gold?
Dean: P. Diddy?

Sam: Who would want virgins?
Dean: You've got me. I prefer ladies with experience.

Dean: I've decided. I'm going to give Stan my most precious gift.
Sam: Wow. That sounded really creepy coming out of your mouth.

I'm gonna rip you apart from the inside out. Do you understand me?

Dean: Until we get you back on your soul train, I'll be your conscience.
Sam: So you're saying you'll be my Jiminy Cricket.
Dean: Shut up. But yeah you fricken puppet, that's exactly what I'm saying.

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean