Vanessa: Serena, I know you like him, but as your friend, Julian is the most self-absorbed pompous person I have ever met. All he does is go on and on about classic movies and it's totally annoying.
Serena: You were keeping up with him pretty good there.
Vanessa: Yeah. And I'm totally annoying.

Georgina: Why won't he respond to any of my calls or my texts or my animated e-cards?
Vanessa: Are you serious?
Georgina: The last one I sent him was this adorable singing dog.
Vanessa: Okay. Dan didn't write you back because (a) he broke up with you, (b) he's seeing someone else, and (c) even though I tried to defend you, you're a full-on crazy person.
Georgina: Wait, can we go back to (b) for a second?

Vanessa: What other possible reason could there be in the God-I-Don't-Believe-In's Universe for Georgina Sparks to be leaving lingerie around your house?
Dan: Meet Milo. He's our son.

Vanessa: Calling him won't look desperate?
Jenny: It will. It will. It will. But in a cute, romantic way.

Dan: It's a really weird, embarrassing thing for a college guy to be admitting but ... losing Milo broke my heart.
Vanessa: I know. Mine too.

Dan: Sorry, I'm so tired lately, Milo's been really colicky.
Vanessa: The fact that you even know what that means is scary.
Dan: You'd be shocked at what I know about breast milk, baby poop, and episiotomies.
Vanessa: Wow, do not mention her Geor-gina.

Vanessa: What happened at the Hudson this morning ... wasn't what it looked like.
Nate: What do you mean?
Vanessa: The guy you and Tripp saved? He didn't fall. I think it was set up.
Nate: That's ridiculous.
Vanessa: I have it all on tape.

I know I'm an enemy of the state right now, but what happened to you Nate? The guy I used to call my friend ... had a moral compass.

[to Dan] By the way, I'm not wearing any underwear.

Vanessa: This could be the best satire on the Upper East Side since Bonfire of the Vanities. How long have you been working on this?
Dan: Five years, off and on.

Dan: I gotta be honest, I really like Olivia ...
Vanessa: Dan, you're WAY off base right now.
Dan: ... and I've always cared about you, but ...
Vanessa: Stop! I'm not in love with you, you moron. Georgina's been blackmailing me.
Dan: What? Why? Look, Vanessa, I'm your best friend. You can tell me, you have to tell me. What does she have on you?
Vanessa: She knows that I know Scott is your brother.

Dan: I'm glad you got in.
Vanessa: You are?
Dan: Yeah, and hey, they also wished me the best of luck in my future endeavors. So, not a total loss.

Gossip Girl Quotes

Even Blair Waldorf can not bend DNA to her will.

Dan

Hazel: Do you know what you're doing, Little J?
Jenny: I'm not Little J anymore.