Serena: You know this isn't her fault. She needs help. The last time that this happened she ended up wandering through the snow in her bare feet.
Vanessa: Yeah. After she Single White Female'd her college roommate.
Serena: Rufus said the girl's boyfriend led her on.
Vanessa: Fine. She's in your dress with your ex. But if you're so concerned about Charlie you find her and I'll find Dan.

Serena: You know maybe I should be the one to tell Dan what's going on. At least he considers me a friend, which is more than you can say right now.
Vanessa: And who's fault is that?
Serena: Yours.

Vanessa: I have to ask, as will Rufus - are you sure Milo's yours?
Dan: Of course he is. I mean I'm pretty... I'm pretty sure.
Vanessa: You didn't have a paternity test?

Vanessa: So all my heartfelt attempts to save our friendship had no impact, but the aroma of cheese and dough turned you instantly sentimental?
Dan: They do say that sense of smell is most associated with memory.

Vanessa: You didn't need to have your cousin make me look like a crazy, jealous bitch to Dan.
Serena: Oh you don't need any help with that.
Vanessa: She said I manipulated her to ruin Rufus' business dinner. You're telling me that innocent cousin Charlie came up with that by herself?
Serena: I'm saying you probably did whatever she said you did. If Charlie's fighting back, good for her. She's learning.

Vanessa: So much for the ultimate college experience.
Olivia: What? No. I have had the ultimate experience. With you guys. They say the friends you meet here last a lifetime. You guys want to get out of here?
Dan: Absolutely.

Dan: I'm glad you got in.
Vanessa: You are?
Dan: Yeah, and hey, they also wished me the best of luck in my future endeavors. So, not a total loss.

Dan: I gotta be honest, I really like Olivia ...
Vanessa: Dan, you're WAY off base right now.
Dan: ... and I've always cared about you, but ...
Vanessa: Stop! I'm not in love with you, you moron. Georgina's been blackmailing me.
Dan: What? Why? Look, Vanessa, I'm your best friend. You can tell me, you have to tell me. What does she have on you?
Vanessa: She knows that I know Scott is your brother.

Nate: Look, the polls close in a few hours. Can't you just wait?
Vanessa: I wish I could! This is not some high school thing with Blair and the mean girls, this is someone running for public office, Nate.

Dan: So I wrecked Blair's birthday and I betrayed Nate, I disappointed my dad. And as the icing on the cake I pretty much ruined his and Lily's anniversary.
Vanessa: Other than that, how was your night?

Face it, at the end of the day you're an outsider just like me. And if it's ever between one of us and Serena van der Woodsen, they will always choose Serena.

[to Dan] Please tell me it was Blair and not Georgina!

Serena and Vanessa

Gossip Girl Quotes

Even Blair Waldorf can not bend DNA to her will.

Dan

Hazel: Do you know what you're doing, Little J?
Jenny: I'm not Little J anymore.