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Meredith: My mother disappeared right in front of me. Everything she had, everything she was. Her dignity, her memory. In the end she wasn't even my mother anymore.
Derek: Izzie is not your mother. She doesn't have an untreatable brain condition. She has a tumor, and it can be treated. Don't make this personal Meredith.
Meredith: I wasn't.
Derek: You went to Izzie, as a friend, and you made up her mind for her. So, now as my resident, you go back there and change it! Because this tumor will kill her!