I learned my lesson while I was away Dean. I serve Heaven, I don't serve man. And I certainly don't serve you.

Castiel

Sam:You have to come with us.
Jimmy:How long? And don't give me that "cross that bridge when we get to it" crap.
Sam: Don't you get it? Forever. The demons will never stop. You can never be with your family. So, you either get as far away from them as possible. Or you put a bullet in your head, And that's how you keep your family safe. But there's no getting out and there's no going home.
Dean: Don't sugarcoat it, Sam.

Dean: Cas, hold up. What were you going to tell me?
Castiel: I learned my lesson while I was away Dean. I serve Heaven, I don't serve man. And I certainly don't serve you.

Dean: What were you doing anyway?
Sam: I went for a Coke.
Dean: Was it a refreshing Coke?

Dean: Cas you okay?
Jimmy: Castiel - I'm not Castiel. It's me.
Sam: Who's me?
Jimmy: Jimmy - my name's Jimmy.
Dean: Where the hell is Castiel?
Jimmy: He's gone.

Castiel: We need to talk.
Dean: I'm dreaming, aren't I?
Castiel: It's not safe here... someplace more private.
Dean: More private? We're inside my head.
Castiel: Exactly. Someone could be listening.

Dean: You know I finally get why you and dad butted heads so much. You two are practically the same person. I mean I worshipped the guy, y'know: I dressed like him, I acted like him, I listened to the same music. But you are more like him than I will ever be. I see that now.
Sam: I'll take that as a compliment.
Dean: You can take it any way you want.

Graveyard Caretaker: Tell me, Agent Nugent, have you thought about where you might like to spend eternity?
Dean: All the damn time.

Sam: No wonder none of the tests worked. You're not shapeshifers. You're ghouls.
Kate: You know, I find that term racist.

Adam: Okay, so basically you're saying that every movie monster, every nightmare that I've ever had, that's all real.
Dean: Godzilla's just a movie.

Dean: Adam doesn't have to be cursed.
Sam: He's a Winchester. He's already cursed.

Dean: I'm starving, lets get breakfast.
Sam: Where? We're like two hours from anything.
Dean: But I'm hungry now.
Sam: There is probably still a sandwich in the backseat.
Dean: It's tuna.

Supernatural Season 4 Quotes

Sam: It's probably a dumbwaiter. All these old houses had them.
Dean: Know-it-all.
Sam: What?
Dean: What?
Sam: You said...
Dean: What?
Sam: Never mind.

Boy, three bedrooms, two baths, and one homicide. This place is going to sell like hotcakes.

Dean