Leonard: How do you get an entire lecture hall to flip you off at the same time?
Howard: Apparently if you're Sheldon all you have to do is turn your back.

I was expecting applause but I suppose stunned silence is equally appropriate.

Sheldon

Howard: Oh I'm not hot enough for Angelina Jolie?
Raj: I'd like to weigh in here: No.

I'd like to raise two points, #1 I think they are talking about penises, and #2 these Mimosas are kicking my little brown ass.

Raj

I'm the kind of girl who can get all the giant missiles she wants.

Bernadette

Please tell me you are not having coitus.

Sheldon

Sweetie, let me put this in a way you'll understand. From the waist down, my shields are up.

Penny

I'm prone to night terrors, so if I wake up kicking and screaming, don't panic. Just pin me down and stroke my hair and I'll be fine.

Amy

Radio contact is sufficient, no need to extend your middle finger.

Sheldon

She made the case that if we break down in the middle of nowhere, your Nebraska backwoods skills and brawny hands will give us the best chance to survive in the wild.

Sheldon [to Penny]

Nobody cares about your Kegel exercises.

Howard

Remember people we're only as strong as our weakest bladder.

Sheldon

The Big Bang Theory Season 4 Quotes

Leonard: Hi. I'm Leonard. You are beautiful. You pop, sparkle and buzz electric. I'm going to pick you up at eight, show you a night you will never forget.
Raj: Where are we going?

You have broad hips and a certain corn-fed vigor. Is your womb available for rental?

Sheldon