- Mrs. O’Malley comes in for surgery after a botched procedure at another hospital. The residents talk about George and Callie spends time with her former mother in law.
- Derek and Lexie perform surgery on an author who connects with Lexie.
- Teddy and Henry have their first big fight. Teddy comes home to him coughing up blood.
- Cristina prepares her list of surgeries for Teddy after working on a heart in a box.
- Jackson avoids surgery with Mark because of Lexie so he breaks up with her and chooses Mark.