Leonard: Hi. I'm Leonard. You are beautiful. You pop, sparkle and buzz electric. I'm going to pick you up at eight, show you a night you will never forget.
Raj: Where are we going?

Leonard: 'Sup
Sheldon: 'Sup

Leonard: So, I've got a gunshot wound. That's pretty bad-ass.
Penny: No, you've got a Reebok with a gunshot wound and an ouchie on your pinky toe.

Rajesh: Isn't there a University policy against dating graduate students?
Leonard: No. If you can talk to them, you can ask them out.
Rajesh: Damn, there's always a catch

Sheldon: What happens if you use argon lasers instead of helium-neon?
Leonard: It would blow up!
Sheldon: Are you sure?
Leonard: Pretty sure...
Sheldon: Pretty sure? It's not very scientific. Is this how you normally work? Just hunches and guesses and stuff?

Leonard: How long is [Leo] going to stay here?
Sheldon: He's a homeless drug addict, Leonard. Where's he going to go? Boy, you have a lot to learn about lying

Penny: You mean like a beta test?
Leonard: Well, technically, this would be an alpha test. A beta test requires people that weren't involved in the development of the appli....
Penny: Seriously, do I not get credit for knowing beta test?
Leonard: No, absolutely you should.

Howard: It's amazing people keep coming to comic book stores instead of just downloading comics digitally.
Leonard: It's probably for the best. For a lot of these guys, the weekly trip here is the only chance their mom has to go down to the basement to change their sheets.
Howard: Oh, that reminds me, I get fresh sheets tonight. Yay!

Raj: The guy who plays Jon Snow was a jerk and we still watch Game of Thrones.
Leonard: He was a jerk because you rear-ended him.
Raj: I was distracted. It's weird seeing a member of the Night's Watch with kayak strapped to his car.

Raj: Wool pants in the desert. I feel like I've got poached testicles.
Leonard: Oh, you poor thing, you're sweating. That is so much worse than having your car stolen.
Raj: Your insurance is going to buy you a new car. It's not gonna de-funk my junk.

Leslie: Listen, neither of us are neuroscientists, but we both understand the biochemistry of sex. I mean, dopamine in our brains is released across synapses, causing pleasure. You stick electrodes in a rat's brain, give him an orgasm button, he'll push that thing until he starves to death.
Leonard: Well, who wouldn't?
Leslie: Well, the only difference between us and the rat is that you can't stick an electrode in our hypothalamus. That's where you come in

Leonard [about the time machine]: The lights flash, and the dish spins. You wanna try it?
Penny: No, I don't wanna try it! My God, you are grown men! How could you waste your lives with these stupid toys and costumes, and comic books, and-and... now that-that...
Sheldon: Again—time machine.
Penny: Oh, please, that's not a time machine. If anything, it looks like something Elton John would drive through the Everglades

TBBT Quotes

It's very simple. Scissors cuts paper, paper covers rock, rock crushes lizard, lizard poisons Spock, Spock smashes scissors, scissors decapitates lizard, lizard eats paper, paper disproves Spock, Spock vaporizes rock, and, as it always has, rock crushes scissors

Sheldon

Sheldon: Why do you have the Chinese character for "soup" tattooed on your right buttock?
Penny: It's not "soup," it's "courage."
Sheldon: No it isn't. But I suppose it does take courage to demonstrate that kind of commitment to soup.
Penny: How'd you see it? You said you wouldn't look.
Sheldon: Sorry. As I told you, the hero always peeks.