Penny: Prom is silly anyways.
Bernadette: Easy for you to say; you probably went with the captain of the football team.
Penny: No. I just made out with him a little while his date was puking.

Penny: That, believe it or not, is my prom dress.
Bernadette: Wow, you still have it? I just assumed it was balled up in the corner of a barn somewhere.
Penny: What kind of teenager did you think I was?
Bernadette: Slutty.
Amy: Easy.
Penny: The word is "popular."

Sheldon: But you don't have a life-threatening condition. Why would you take the risk of surgery?
Leonard: Sheldon, it's a routine procedure.
Penny: I've heard you complain about his snoring.
Sheldon: We... Yes, for the first five or six years, but I've gotten used to it. It helps me sleep. He's like my mucus-powered white noise machine.

Sheldon: I assume this medical center's already treated the burns on your bottom from the recent pants fire.
Penny: 'Cause I'm a liar, liar?
Sheldon: That's for the fire marshal to determine.

Penny: Okay, the reason he deceived you is you were being
a pain in the ass.
Sheldon: The reason I was being a pain in the B is because I was worried about him, and no one else was.
Penny: Really? You won't even say "A"?
Sheldon: You bet your sweet B I won't.

Dan: Bernadette. Cute, sweet...vicious little Bernadette.
Penny: Come on. She's not that bad.
Dan: Oh, yeah? At the company picnic she yelled at me and my grandson for losing the three-legged race. I mean, he still calls her "that mean kid with the big boobies."

TBBT Quotes

Sheldon [to Kripke]: Also, I am given to understand that your mother is overweight.
Raj: Oh, snap.
Sheldon: Now of course, if that is the result of a glandular condition and not sloth and gluttony then I withdraw that comment.

How is "doable" anything but a compliment?

Wolowitz