Sheldon: You hypocrite!
Penny: What?
Sheldon: Little Miss 'Grown-ups don't play with toys', if I went into that apartment right now, would I not find Beanie Babies? Are you not an accumulator of Care Bears and My Little Ponies? And who is that Japanese feline I see frolicking on your shorts? Hello, Hello Kitty!

Penny [to Leonard]: Look, you are a great guy, and it is the things you love that make you who you are.
Wolowitz: I guess that makes me large breasts

Leonard [about the time machine]: The lights flash, and the dish spins. You wanna try it?
Penny: No, I don't wanna try it! My God, you are grown men! How could you waste your lives with these stupid toys and costumes, and comic books, and-and... now that-that...
Sheldon: Again—time machine.
Penny: Oh, please, that's not a time machine. If anything, it looks like something Elton John would drive through the Everglades

Penny [on phone]: How about this, you keep him there a little longer, and when you get to the party, I'll point out which of my friends are easy.
Wolowitz: ... Don't toy with me, woman.
Penny: I got a hot former fat girl with no self-esteem, I got a girl who punishes her father by sleeping around, and an alcoholic who's two tequila shots away from letting you wear her like a hat.
Wolowitz: Thy will be done

Leonard: How did you know my birthday's Saturday?
Penny: I did your horoscope, remember? I was going to do everybody's until Sheldon went on one of his typical psychotic rants.
Sheldon: For the record, that psychotic rant was a concise summation of the research of Bertram Forer, who, in 1948, proved conclusively through meticulously designed experiments that astrology is nothing but pseudoscientific hokum.
Penny: Blah, blah, a typical Taurus

Leonard: I don't celebrate my birthday.
Penny: Shut up. Yeah, you do.
Leonard: It's no big deal. It's just the way I was raised. My parents focused on celebrating achievements and being expelled from a birth canal was not considered one of them

Penny: Well, Sheldon you are his friend. Friends give each other presents.
Sheldon: I accept your premise; I reject your conclusion.
Wolowitz [whispers]: Try telling him it's a non-optional social convention.
Penny: What?
Wolowitz: Just do it.
Penny: It's a non-optional social convention.
Sheldon: Ahh, fair enough.
Wolowitz: He came with a manual

Sheldon: Leonard made it very clear, he doesn't want a party.
Wolowitz: Did someone say party?
Penny: He just doesn't know he wants one because he never had one.
Wolowitz: I suppose that's possible, but for the record I've never had a threesome and yet I still know I want one.
Penny: Howard here's a difference: the possibility exists that Leonard could have a birthday party before hell freezes over.
Wolowitz: Fine, if I do have a threesome you can't be part of it... I'm just kidding. Yes, you can. Can you bring a friend?

Penny: Maybe we should talk first.
Leonard: Okay, but before you say anything, have you ever heard of Schrödinger's cat?
Penny: Actually, I've heard far too much about Schrödinger's cat.
Leonard: Good.
[Leonard kisses Penny]
Penny: Alright, the cat's alive. Let's go to dinner

Penny: I was just wondering if I could talk to you. It's about Leonard.
Sheldon: Why me? Why not Koothrappali or Wolowitz?
Penny: Well, Raj can't talk to me unless he is drunk, and Wolowitz is, you know, disgusting

Penny: I swear to God, I am done with guys like that. You know, macho with the perfect body and hair, and money.
Leonard: Yeah, that must get old quick

Penny: I'm a Sagittarius, which probably tells you way more than you need to know.
Sheldon: Yes, it tells us that you participate in the mass cultural delusion that the sun's apparent position relative to arbitrarily defined constellations at the time of your birth somehow affects your personality.
Penny: Participate in the what?

TBBT Quotes

Oh, Bernadette, please play my clarinet.

Raj's poem

Sheldon: I'll have a diet Coke.
Penny: Can you please order a cocktail? I need to practice mixing drinks.
Sheldon: Fine... I'll have a virgin Cuba Libre.
Penny: That's... rum and Coke without the rum.
Sheldon: Yes, and would you make it diet?