Dean, did you service Oberon, King of the Fairies?

Sam: So you're saying having a soul equals suffering?
Dean: Yes, that's exactly what I'm saying.

Sam: What about when there are no more leads for that? I mean are you just supposed to sit there in the dark and suffer, even when there's nothing that can be done at that moment?
Dean: Yes! You sit in the dark and you feel the loss.
Sam: Absolutely, but couldn't I just do all that and have sex with the hippie chick?
Dean: No!

Dean: They're after me!
Sam: Third kind, already? You better run, man. I think the fourth kind is the butt thing.
Dean: Empathy, Sam. Empathy!

Dean: You don't care. You have to care.
Sam: About what exactly?
Dean: About everything!

We do what we got to do and we get my brother back.

Sam: Why shack up with a family? Is it a kinky thing? Do you like to play with your food? Roll over, Lucky. Speak.
Lucky: Go to hell.
Sam: Already been. Didn't agree with me.

Dean: Ok time to go. Now, we can either do this the easy way or the hard way.
Sam: (laughs) What? Soul or not, that's funny.

Dean: Who, whoa, whoa, wait? You two know each other?
Crowley: Not in the biblical sense, more of a business relationship I'd say.
Sam: [to Samuel] You're Crowley's bitch.

Ever since I came back, I am a better hunter then I've ever been! Nothing scares me anymore, because I can't feel it. I don't know what's wrong with me. I think I need help.

Dean: Try uh, Lautner.
Sam: He's a werewolf. How do you even know who that is?
Dean: What are you kidding me? That kid is everywhere. It's a friggen nightmare.

Sam: Dean, he's a dick, but a deals a deal.
Crowley: I don't need you to fight my battles for me, moose. Get bent.

Supernatural Quotes

Boy, three bedrooms, two baths, and one homicide. This place is going to sell like hotcakes.

Dean

Dean: Do I know you?
Becky: No, but I know you.