Sheldon: In Texas, when a cow stops giving milk, they don't continue feeding her. They take her out and shoot her between the eyes.
Penny: I'm confused. Did Sheldon stop giving milk?

Leonard: You always knew that someday someone would come along who was younger and smarter.
Sheldon: Yes, but I assumed I would have been dead hundreds of years and that there'd be an asterisk next to his name because he'd be a cyborg

Engineering, where the semi-skilled laborers execute the vision of those who think and dream

Sheldon: What happens if you use argon lasers instead of helium-neon?
Leonard: It would blow up!
Sheldon: Are you sure?
Leonard: Pretty sure...
Sheldon: Pretty sure? It's not very scientific. Is this how you normally work? Just hunches and guesses and stuff?

Sheldon: Here's the problem with teleportation.
Leonard: Lay it on me.
Sheldon: Assuming a device could be invented, which would identify the quantum state of matter of an individual in one location and transmit that pattern to a distant location for reassembly. You would not have actually transported the individual, you would have destroyed him in one location and recreated him in another.
Leonard: How about that.
Sheldon: Personally, I would never use a transporter because the original Sheldon would have to be dissintegrated in order to create a new Sheldon.
Leonard: Would the new Sheldon be in any way an improvement on the old Sheldon?
Sheldon: No, he would be exactly the same.
Leonard: That is a problem

Ladies and gentlemen... honored daughters... while Mr. Kim, by virtue of his youth and naivety, has fallen prey to the inexplicable need for human contact, let me step in and assure you that my research will go on uninterrupted and that social relationships will continue to baffle and repulse me. Thank you

Leonard: You speak English really well.
Dennis: So do you... except for your tendency to end sentences with prepositions.
Leonard: What are you talking about?
Dennis: That.
Sheldon: He's not wrong

The local cuisine was a little more sausage-based than I'm used to, and the result was an internal blitzkrieg, with my lower intestine playing the part of Czechoslovakia

[at The Cheesecake Factory]
Penny: Why didn't you just have soup at home?
Sheldon: Penny, I have an IQ of 187. Don't you imagine if there were a way for me to have soup at home, I would have thought of it?
Penny: You can have soup delivered.
Sheldon: I did not think of that

Leonard: Sheldon, don't you think you're overreacting?
Sheldon: When I'm lying comatose in a hospital, relying on inferior minds to cure me, these Jell-O cultures and my accompanying notes will give them a fighting chance

Sheldon: Checkmate.
Leonard: Argh, again?
Sheldon: Obviously you're not well-suited for three-dimensional chess. Perhaps three-dimensional Candyland would be your speed

Leonard: Alright, get some rest and drink plenty of fluids.
Sheldon: What else would I drink? Solids? Gases? Ionized plasma?
Leonard: Drink whatever you want

TBBT Quotes

Oh, Bernadette, please play my clarinet.

Raj's poem

Sheldon: I'll have a diet Coke.
Penny: Can you please order a cocktail? I need to practice mixing drinks.
Sheldon: Fine... I'll have a virgin Cuba Libre.
Penny: That's... rum and Coke without the rum.
Sheldon: Yes, and would you make it diet?