Keep laughing, or I will slit your throat in your sleep.

Karen

Brush your teeth, I wanna play.

Fiona

Tourettes coupled with bipolar disorder and a drinking problem, he's a shrink's wet dream.

Veronica

Is that like a sibling brother? Or like a black guy brother.

Lip

That's the problem, there should only be two testicles invited to this party.

Doctor

Other than the presents and the booze, can you tell me three good reasons we should get married?

Veronica

Here's the happy couple, Kevin and Veronica, may you always have two testicles between you. L'Chiam!

Frank

I bet it itches like you got crabs in there.

Frank [to lady in body cast]

I'm a 60-year-old lady with the vag of a newborn.

Fiona

Fiona: Debbie stole a baby; we have to figure out how to return it.
Lip: Why?
Fiona: It's Debbie.

Oh don't mind me, I accidentally took three of my pills instead of one.

Sheila

Frank: Beautiful day for a party!
Neighbors: It's for kids, Frank. No booze!

Shameless Quotes

Everytime she pees on the stick it's bad news and then I get depressed thinking about my husband banging my mom cause we selfishly wanna have a baby with some of our DNA.

V

Gus: See you at two.
Fiona: Wouldn't miss it.