Sam: What kind of thing likes virgins and gold?
Dean: P. Diddy?

Sam: Who would want virgins?
Dean: You've got me. I prefer ladies with experience.

Dean: I've decided. I'm going to give Stan my most precious gift.
Sam: Wow. That sounded really creepy coming out of your mouth.

Victim of Death [to Dean]: Wait. Will you tell me what it all means?
Dean: Everything is dust in the wind.
Victim of Death: That's it? A Kansas song?
Tessa: Sorry. He's new.

I'm gonna rip you apart from the inside out. Do you understand me?

Sam (to Lucifer)

Shawshank's a great flick, but let's skip the shower scene.

Dean

Best purchase I made since Dick Cheney.

Crowley

I learned that from the pizza man.

Castiel

Karma's a bitch, bitch.

Dean

Seacrest, out.

Meg

You boys have serious abandonment issues, don't you?

Meg

Samuel: Is this what you boys do, sit around watching pornos with angels?
Castiel: We're not supposed to talk about it.

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean