Kind of makes you nostalgic for good old fashioned herpes.

Dean

Woman: What kind of FBI agents are you?!
Dean: The fake kind.

What's a dad bod?

Dean

As long as everyone wears a condom we'll be fine.

Jody

What’s done is done. All that matters now, all that’s ever mattered, is that we’re together. So shut up, and drink your beer.

Dean

Dean: I always did have a thing for Blanche on Golden Girls.
Sam: Seriously?
Dean: Hey, don’t judge what you don’t understand, Sammy.
Sam: No, I’m not judging. I just always had a thing for Sophia.
Dean: Yeah, I can see that.

I’m here to save you all. Lucifer ex machina.

Lucifer

Sam: Turns out Harold was stealing the other residents' Viagra.
Dean: I know. It's a real dick move.

Dean: Your hand is still on my knee.
Mildred: I could move it up.

Snapping necks and cashing checks, it's what i do.

Lucifer

Dean: Where's Sam?
Crowley: Don't worry about Sam.
Dean: Oh I'm sorry, have you met me?

Get the hell out of hell.

Crowley