Mercer: I'm just policing myself because we all know how easy it is to judge another culture's way of life just because it's alien to us.
Grayson: But you have to balance that against some universal code of ethics

Grayson: I'd have been pretty pissed off if my parents had made the unilateral decision to make me a guy.
Mercer: And, while it may have saved me an entire marriage if they had, it still would've been wrong.

Being a girl is not a condition. There are no health risks. Having a vagina doesn't give you a lisp. I mean, depending on how you use it.

Mercer

Vasquez: Perhaps we settle this the traditional way
Mercer: You mean a show down. If that's the way you want it.
Vasquez: No, senor. We will have a dance contest.... I have taken many years of jazz and tap. If you can beat me in a dance-off, I will surrender.

I am a Union doctor on a Union ship and I will not perform a sex change on a newborn infant

Dr. Finn

Yaphit: And then there's this cough. *cough* *cough* right?
Dr. Finn: You don't have lungs which means you don't have a cough.

Dr. Finn: Yaphit, there's nothing wrong with you
Yaphit: Oh, I'm pretty sure there is, doc. I haven't been retaining fluids like I usually do. My quarters look like a swamp. It's a mess.

Calivan 1: The Bachelor, Duck Dynasty, Keeping Up with the Kardashians...
Calivan 2: There must be ten thousand files here. What is this... reality television?
Calivan Zoo Administrator: The best exhibit we've ever had.

Mercer: I'M GOING TO THE BATHROOM TO READ!
Grayson: What the hell was that?
Mercer: Elvis Presley's last words. It was all I could think of.

Isaac: They were in the midst of treatment for a very rare disease they are carrying, one that could infect your other species.
Calivon: You're kidding
Isaac: I am Kaylon. We do not kid.

Calivon: If you're going to try to sell me that Xelayan female, I've already got one.
Isaac: She is not for sale. She is... my pet.
Kitan: Woof

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Grayson: You should try eating in the morning instead of drinking. It's neat.
Mercer: I'm having A beer.
Grayson: Yeah. At nine AM.

The Orville Quotes

Mercer: I know Gordon has his issues but we all know that there's nobody that can drive a starship like him.
Admiral: Didn't he once draw a penis on the main viewing screen of Outpost T-85?
Mercer: He's drawn a lot of penises on a lot of things.

Mercer: I've had some personal stuff that's been going on... It's not really worth going into... Can I have one of these mints?
Admiral: Those are marbles.