Grampa: Why I go in and out of coma's all the .............. french toast please.
Lisa: Is a coma painful?
Grampa: Oh heck no. You relive long lost summers, kiss girls from high school. It's like one of those TV shows where they show a bunch of clips from old episodes.

TV Announcer: The following is a public service announcement. Excessive alcohol consumption can cause liver damage and cancer of the rectum.
Homer: Mmm... beer.

I am interested in long-distance savings. Very interested.

Squeaky-Voiced Teen

Oh Marge. What if I wind up as some vegetable watching TV on the couch. My important work will never be completed.

Homer

Mrs. Simpson, I'm afraid your husband is dead. (classic laugh) April Fools. He's very much alive, although I'm afraid he may never walk again.

Dr. Hibbert

Marge: You lost 5% of your brain.
Homer: Me lose brain? Uh-oh! (Everyone including Homer laughs)
Homer: Why I laugh?

Moe: I brought you a little present. (Gives Homer a can of beer)
Homer: No. Beer bring pain.
Barney: I can't stand to see him like this. (Shoves a pillow in Homer's face. He than lifts up a water fountain, throws it at a window, jumps out and runs away)
Moe: He really needs a girlfriend.

It's a good thing that beer wasn't shooken up any more, or I'd have looked quite the fool. An April Fool, as it were.

Homer

Homer: And that's the story of April Fools Day.
Lisa: Dad, I was telling the story!

Look at them all through the darkness I'm bringing, they're not sad at all, they're actually singing.

Mr. Burns

Kent: Homer, organised labor has been called a lumbering dinosaur.
Homer: AAAAHH!
Kent: Um, my director is asking me not to talk to you anymore.
Homer: Woohoo!

Dentist: I'm afraid Lisa is going to need braces.
Lisa: Oh no! I'll be socially unpopular...more so!

The Simpsons Season 4 Quotes

Marge: Homer, you do remember your promise to the children?
Homer: Sure do. When you're eighteen, you're out the door!

Marge: Lisa, watch out for poison ivy. Remember, leaves of three, let it be.
Homer: Leaves of four, eat some more! (Laughs)