Can the doctors do it? Or is this the last we've seen of them?
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Or doing the best they can. George was a hero for what he did.
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Alex reacts as Izzie slips away from him, possibly for the last time.
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Is Izzie about to slip away into the afterlife?
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Meredith and John Doe (who we now know to be George) in the season five finale of Grey's Anatomy.
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Alex calls for help as Izzie fades into unconsciousness.
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Cristina and Izzie share a moment in "Now or Never."
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Meredith finally learns the identity of John Doe. And it's shocking.
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Grey's Anatomy Season 5 Quotes

Minister: Dearly beloved. We are gathered here today to celebrate the wedding of Alexander Michael Karev and Isobel Katherine Stevens. This is a sacred right. An ancient right. As Isobel and Alex prepare to join their lives, it is important to understand that everyone present has played a part in shaping their lives. And, will continue to play a vital role in their continuing future. And thus, we are here not only to witness their vows to each other, but to bestow upon them our blessing. And, now the couple will read their vows.
Izzie: Oh, we didn't write anything.
Alex: No, wait. I have something I wanna say. Today's the day my life begins. All my life I've been just me. Just a smart mouth kid. Today I become a man. Today I become a husband. Today I become accountable to someone other than myself. Today I become accountable to you. To our future. To all the possibilities that a marriage has to offer. Together, no matter what happens, I'll be ready. For anything. For everything. To take on life, to take on love. To take on possibility and responsibility. Today Izzie Stevens, our life together begins. And I for one can't wait.
Izzie: I love you. (kisses him)
Minister: Ahem, not yet!
Alex: Hurry up!
Minister: By the power vested in me, by god and the state of Washington, I now pronounce you husband and wife.
Izzie: Now?
Minister: Now.
(Izzie and Alex kiss)

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)