Izzie: (on phone) George, it's me. You know, I pretty much died not too long ago so I need you to call me back. Please. I know, I played the cancer card. I'm gross. Whatever.
Alex: I need to tell you something, and I need you to not panic. I need you to keep breathing. I need you to stay alive. I swear to god, I need you to stay alive. Alright?
Izzie: Ok.
Alex: O'Malley, he got in an accident. He's brain-dead.
Izzie: I'm sorry, what?

Callie: She's strong enough. She's strong enough, and you have to tell her.
Alex: Why? It can wait.
Callie: No! It can't. It can't wait because George's organs are not gonna be viable for long. If they want to use them they have to do it soon and I have to decide if they get to use them. And, I need Izzie to help me, because she's the one who should decide. She's who should decide. So that's one reason. And... the other reason is... Karev, if you let them unplug George without giving her a chance to say goodbye, I mean it, she will never forgive you. You have to tell her!

Alex: You can't tell her!
Meredith: Alex.
Alex: She coded in my arms. Out of nowhere, she died. Just... I'll tell her. I'll tell her when she gets stronger.
Izzie: (calls from her room) Alex...
Alex: You ok?
Izzie: I had a dream. He was in his uniform.
Alex: What?
Izzie: George is gonna die in the army if we don't stop him. Hand me my phone, I need my phone.

Alex: Woah, woah... she wants it out. Can't we take it out?
Cristina: She's breathing over the vent.
Richard: Alright, let's pull out the tube.
Meredith: (appears) Dr. Bailey...

Meredith: You're laughing?
Alex: She's laughing.
Izzie: [laughing] George is dead! He's dead! They're about to put him in the ground and the priest is doing classic rock lyrics! And that girl, that redhead, is crying harder than his mother and she never even met him!
Cristina: You are far more twisted than I ever realized.

Izzie: You got married on a post-it!
Meredith: I got married on a post-it.
Cristina: You guys got married for real!
Izzie: I got cancer!
Alex: O'Malley got hit by a bus!
[all laugh hysterically]

Arizona: McDreamy.
Alex: Sorry.
Arizona: I get it now. The whole McDreamy thing. I didn't get it before, but now I totally get it. You know they call you that, right?
Alex: Yes.
Arizona: I'm involved, by the way. In case you thought I was coming onto you just now, which I was not. Plus I heard you got married, by the way. So, congratulations!
Derek: Yes, thank you.
Alex: He wrote some hokey crap on a post-it note in the residents' lounge. Sorry but until you're sweating it out in a morning coat, you're not really married.
Derek: I've consummated mine. I consummate mine all the time. How's that going for you Karev? Girls talk. You might want to think about that the next time you criticize my post-it.

Alex: What is this?
Izzie: Take off your pants.
Alex: Iz, it's a...
Izzie: Be my husband, get undressed, get into bed and hold me. I don't know what you're so mad about and I don't know what you're scared of because you won't talk to me. But, I'm scared too Alex. And I can't... if you won't... If we're gonna have any chance at a life together then I need you to. Please...
Alex: You died in my arms. You died in my arms! You freakin died, and then you left instructions that I wasn't allowed to save your life. You wanna know what I'm scared of? I'm scared of everything. I'm scared to move. I'm scared to breathe. I'm scared to touch you. I can't lose you. I won't survive. And that's your fault. You made me love you, you made me let you in. And then you freaking died in my arms.

Lexie: [narrating] Grief may be a thing we all have in common, but it looks different on everyone.
Mark: It isn't just death we have to grieve. It's life. It's loss. It's change.
Alex: And when we wonder why it has to suck so much sometimes, has to hurt so bad. The thing we gotta try to remember is that it can turn on a dime.
Izzie: That's how you stay alive. When it hurts so much you can't breathe, that's how you survive.
Derek: By remembering that one day, somehow, impossibly, you won't feel this way. It won't hurt this much.
Bailey: Grief comes in its own time for everyone, in its own way.
Owen: So the best we can do, the best anyone can do, is try for honesty.
Meredith: The really crappy thing, the very worst part of grief is that you can't control it.
Arizona: The best we can do is try to let ourselves feel it when it comes.
Callie: And let it go when we can.
Meredith: The very worst part is that the minute you think you're past it, it starts all over again.
Cristina: And always, every time, it takes your breath away.
Meredith: There are five stages of grief. They look different on all of us, but there are always five.
Alex: Denial.
Derek: Anger.
Bailey: Bargaining.
Lexie: Depression.
Richard: Acceptance.

Richard: What happened?
Bailey: Is it her brain?
Cristina: No, it's hypokalemia.
Alex: We couldn't control the eurythmias.
Cristina: Her pressures dropping off a cliff.
Alex: Get me an intubation tray.
Cristina: Alex. She signed a DNR.
Alex: Shut up Yang!
Cristina: She knew this might happen, that's why she signed it.
Alex: I don't give a crap what she signed.
Cristina: Alex, it's not what she wants.
Alex: (Izzie flatlines) Get a crash cart! (he starts CPR)
Bailey: Karev, if she doesn't...
Alex: Look at her, get a crash cart!
Richard: Oh, screw the DNR. Hand me those paddles.
Bailey: Yang, take over compressions to her back
Cristina: I got it, I got it.
Richard: 1, 2, 3. (they turn her over) Hand down. Ok. Hand down. Charge to 300.

Alex: Izzie look at me. Open your eyes!
Cristina: Page Shepherd. Page the Chief, and Bailey right now!

Cristina: Way to go dipwad, telling your wife you're figuring out how to off her.
Alex: Oh, mind your own bus... Wait... how did you know that?
Cristina: (holding back tears) She told me.
Alex: (walks into Izzie's room) You remember?
Izzie: Pillow or morphine. I got the whole thing.
Alex: Oh, I'm so sorry. I didn't mean that.
Izzie: Of course you didn't. You love me too much to shoot me up with morphine, even if you asked me to. And my stupid corked brain is coming back.
Alex: (hugging her tightly) Oh my god, I was so scared. I mean I would have loved you no matter what. You're back. You're back. (Izzie goes limp) Izz? (her heart starts to fail) Iz? Izzie? YANG!

Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

I want to marry you. I want to have kids with you. I want to build us a house. I want to settle down and grow old with you. I want to die when I'm 110 years old, in your arms. I don't want 48 uninterrupted hours. I want a lifetime. Mmm. Do you see what happens? I say things like that and you fight the urge to run in the opposite direction. It's okay, I understand. I didn't, but now I do, I do. You're just getting started and I've been doing this for a long time now. Deep down, you're still an intern, and you're not ready.

Derek