Sam: Wait, wait, wait, wait! Talk to me!
Teen Dean: Really Sam? Now? I got no grass on the infield and a girl's gonna die. Sorry if I'm not in a chatty mood. Look. You wanted me back in the game, I'm back in the damn game. C'mon.

Well that's great, because without your power, you're basically just a baby in a trench coat.

Castiel: The only thing you're going to see out there is Michael killing your brother.
Dean: Well, then I ain't gonna let him die alone.

Sam: Were you racing me?
Dean: No, I was kicking your ass.
Sam: Very mature.

Just because you're blood doesn't mean you're family. You have to earn it.

Sam: So, now ah, what's the deal with all this TV crap?
Castiel: Pardon me?
Dean: Yeah, amen Padaleski.
Sam: Padalecki.,
Dean: What?
Sam: -Lecki, I'm pretty sure.

Dean: Seriously. Why? Why would anybody want to watch our lives?
Sam: Well, according to the interviewer, not very many people do.

What kind of douchebag names a character after himself?

Genevieve: You've never even been to our house.
Dean: Well, now that I know there's an alpaca outback, I'm definitely coming back.
Genevieve: Well, alpacas are the greenest animal.

You married fake Ruby?

Sam: What am I? Dracula?
Dean: George Hamilton Dracula.

Dude, we're not even in America.

Supernatural Quotes

You're wrong. I am utterly indifferent to sexual orientation. On the other hand, I cannot abide hypocrites like you, Reverend. Tell your flock where your genitals have been before you speak for me.

Castiel

If you affirmate me, I'm gonna punch you in the face.

Dean