MEREDITH: "Hey."
DEREK: "Well, hey."
MEREDITH: [tries not to laugh] "So, you picked up Doc?"
DEREK: "Yeah, he's home."
MEREDITH: "He seems to be doing better."
DEREK: "Yeah, he's... he's doing good."
MEREDITH: [laughs] "I'm not laughing at you."
DEREK: [laughs] "No."
MEREDITH: "It's just, you know... bad sex isn't the kind of thing that wives want announced to dirty-ex-mistresses."
DEREK: "You're not the dirty ex-mistress. You're a friend. She's your friend. I'm your friend. We're all friends."
MEREDITH: "But you didn't tell her."
DEREK: "No." [smiles] "So how's your day going?"

DEREK: [answers phone] "Hello? Hi. Yeah, yeah." [to Addison] "It's about Doc. No, I'm here... I can pick him up this morning. Sure, I-"
ADDISON: [grabs phone] "Hi, Dr. Dandrige? Listen, we're gonna have to call you back becasue we're trying really hard to have some decent sex here." [hangs up]
MEREDITH: [silence]

ADDISON: "Thanks."
DEREK: [laughs] "Your thanking me for the most boring sex ever!?"
ADDISON: "I didn't know what else to say."

DIVORCE LAWYER PATIENT: "Any of you are looking to get out of a bad marriage?"
GEORGE & IZZIE: [smirking] "No."
DIVORCE LAWYER PATIENT: "Dr. Shepherd?"
DEREK: "Yes. No!"

DEREK: "Addison and I are over, Adele."
ADDISON: "Oh, it's not like we're divorced."
DEREK: "We're practically divorced."
ADELE: [to Addison] "You've had counseling?"
DEREK: "We've had adultery. That was enough."

ADDISON: "We got successful, you and me. We got busy and we got lazy. We didn't even bother to fight anymore, Derek. Mark was there and I missed you and now I'm sorry. I'm more sorry than you could possibly imagine, but at least I'm talking to you about it."
DEREK: "I'm a sink with an open drain, Addie."

RICHARD: "You called my wife?"
DEREK: "You called mine!"

[to Meredith] "So I go upstairs, preparing myself for what I'm going to see when I walk into my bedroom. I step on a man's jacket that doesn't belong to me. Then everything I know... it just shifts. Because what I know now is that when I go into my bedroom, I'm not just going to see that my wife is cheating on me. I'm going to see that my wife is cheating on me with Mark, who happens to be my best friend."

DEREK: "Meredith, I understand..."
MEREDITH: "Do you? Somehow I doubt it. Because if you did, you would shut up, turn around and go back inside, because you would realize that I am this close to getting in my car and running you over in the parking lot!"

PRESTON: "So what's the story with you and Grey?"
DEREK: [pauses] "I got drunk and she took advantage of me. Or she got drunk and I took advantage of her. Well, either way, we were drunk, definitely, and somebody took advantage. I look at it as my initiation into Seattle. What about you?"
PRESTON: "I don't have a story, I just wanted to hear yours."

DEREK: "Addison, what are you doing here?"
ADDISON: "What are YOU doing here? You left everything -- your house, your wife, your practice. You had a life. Now you have a girlfriend in Seattle. She seems... sweet."

ADDISON: "Am I interrupting?"
RICHARD: "You're never interrupting."
DEREK: "She's always interrupting."

Grey's Anatomy Quotes

[walking by Izzie's room]
Meredith: Hot.
Sadie: Horny.

Sexual sorbet? Hahaha! I love it.

Bailey