Eli Loker: Your step-son says you're sleeping together the same time you're bedding daddy. That could breed contempt.
Cal Lightman: Yeah, in my country it's a new member of the royal family.

Clara Musso: Leo couldn't have done it. Victor and Leo were like brothers.
Cal Lightman: So were Brutus and Caesar.

Clara Musso: There seems to be a lot of chemistry there with your ex-wife
Cal Lightman: Yeah, well there's a lot of chemistry in Chernobyl.

Cal Lightman: Nobody can tell the whole truth, it's subjective, and passes through our own filters.
Judge Quinn: How about you promise to be honest to the best of your ability?
Cal Lightman: Now you're talking!

Cal Lightman: All fanatics wash their hands of the blood of the innocent in the name of the cause.
Jimmy Doyle: You're no innocent, Lightman
Cal Lightman: Not by any stretch of the imagination.

Jimmy Doyle: I didn't kill Andrews, I only followed him.
Cal Lightman: Well then, the person who did it wanted us to think you did.

Go ahead Gillian Say it. Doyle's back, he killed Andrews and I am next.

Martin Walker: A good chess player thinks five moves ahead.
Cal Lightman: Great chess players only think one move ahead, but it's always the right move.

Here's the problem, Martin Walker is a psychopath and probably a killer. Just though you should know.

(to Gillian) You know, you were very good back there, with Mrs. Burch. Very nurturing. Maybe you should get a puppy. I could talk to Obama's people.

Hughs: It's been two hours. You think we can trust that pervert?
Cal: Yeah. In my experience, self-castrating pedophiles generally tell the truth.

Ria: When a person's facial expression is not symmetrical across their face, it is likely that they are pretending to feel the emotion. From your article in The Journal of Behavioral Science, 2001.
Cal: Sucking up's not your strong suit, is it?

Lie to Me Quotes

Weil: You haven't done enough muck-raking for one day?
Ria: Sir. We don't think you were doing anything sexual at that club, because, I believe this escort, Melissa, who you paid for time with-
Weil: What about her?
Ria: She's your daughter.

Gillian: Do you still have that note, that I brought you? I want it for my office.
Cal: (handing over the note) You really are a pack rat.
Gillian: You could have just told me what this was for.
Cal: No. You're a terrible liar.
Gillian: Normal people think that's a good thing.