Bernadette: I'm not going to live with your mother. Not now. Not ever.
Howard: Somebody, obviously, has some mommy issues.

Bernadette: I was head-hunted by a big pharmaceutical company. They're going to pay me a buttload of money!!
Leonard: Bernadette, that's great!! Howard, do YOU make a buttload?
Howard: Better than what YOU got a buttload of!

....I volunteered for the premature ejaculation project. I mean, it's not like either one of us has heart disease.

Bernadette to Howard

Howard: You gotta like this. The girlfriend, the ex-girlfriend bonding over your rooty-tooty stinky booty.
Leonard: Kill me.
Sheldon: It wouldn't help. The human body is capable of being flatulent for hours after death.

Howard: You gotta like this: the girlfriend.....the ex-girlfriend, bonding over your rooty-tooty stinky booty?
(all but Leonard laugh)
Leonard: Kill me!
Sheldon: It wouldn't help. The human body is capable of being flatulent for hours after death.

Whereas Jewish mothers take a casual la-dee-dah approach to their sons.

Leonard: Does your family have a history of heart disease?
Wolowitz: My family is the history of heart disease. There's a cave painting in France of one of my ancestors doing this. [mimicks heart attack]

Have you told your parents you're dating this short glass of skim milk?

Her freakishly small hands make anything look big. That's one of the reasons I love her.

Believe in magic, you Muggle!

That crazy bastard is looking at quirky in the rear view mirror.

I think it's like Beetlejuice. We said his name too many times.

TBBT Quotes

Penny: Here's a question-- as an alien pretending to be human, are you planning to engage in any post-prom mating rituals with Amy?
Sheldon: There are post-prom mating rituals?
Penny: Not always. Unless your date drives a van with an air mattress, then always.
Sheldon: Well, if it's part of the prom experience, then I'm open to it.
Penny: You're kidding.
Sheldon: I may be an alien, but I have urges.If Amy wants to copulate by firing her eggs into space, well, then, I will happily catch them with the reproductive sac on my upper flermin. I'm not the best at reading facial cues, but I can see that you're a little turned on.

Sheldon: If you could wake up tomorrow having gained any one quality or ability, what would it be?
Penny: Well, not to steal from the Bible, but turning water into wine sounds pretty good.