Bernadette: You know, one of the things that helped me get through Howard being in space for so long was getting married before he left.
Penny: Bernadette, sweetie, shut up.

Penny: Oh, I don't know. Remember what happened when I took care of your goldfish?
Leonard: Well, flush Sheldon down the toilet and get me a new one.

Oh, sweetie, if you're gonna screw things up, it's gonna be while you're here, not while you're away.

Penny: On a ship? Aren't they afraid Hawking will just roll overboard?
Leonard: Uh, he's not gonna be there. He's just sending a team to research his theory.
Penny: Oh sure. Like when you send me to kill spiders in your bathtub.

Penny: This isn't alcohol. It's a potion that makes me like you.
Leonard: Double potion, please.

Oh, it's not so bad. You lost money, you're filled with shame, and you got groped by a stranger. That's Vegas. You nailed it.

Penny: Vegas here we come.
Bernadette: No husbands. No boyfriends. No rules
Amy: No rules. We're not going to get drunk and have a six-way with the Blue Man Group, are we?
Penny: No.
Amy: So there are some rules.
Bernadette: Okay. No husbands. No boyfriends. Some rules.
Amy: Thank you. VEGAS!

Professor Proton: I'm having trouble with my pacemaker.
Leonard: I'll call for help.
Penny: Any chance we could plug it into the potato?
Professor Proton: No.

Penny: If you don't mind me asking, uh, the potato clock -- how does it work? Is it a trick clock or a trick potato?
Professor Proton [to Leonard]: What do you two talk about?

Professor Proton: I power a clock with a potato.
Penny: Shut up! You can do that? I mean ... wouldn't that solve the world's energy crisis?
Professor Proton: No.

Leonard: It was pretty cool.
Penny: Aw, so cute when you use the word "cool" wrong. Like when kids say "pasghetti."

Leonard: You realize you might kill some of them.
Penny: Oh, then you all can get tenure.

TBBT Quotes

Sheldon: I recently read that during World War Two, Joseph Stalin had a research program to create supersoldiers by having women impregnated by gorillas.
Howard: What a sick use of science.
Raj: Hey, as long as the baby's healthy.
Amy: I wonder if Stalin considered any other animals.
Leonard: Hippos are the deadliest creature. A half-human, half-hippo soldier would be pretty badass.
Howard: Yes, but when they're hungry-hungry, you can stop them with marbles.
Sheldon: Yeah, the correct animal for interspecies supersolider is koala. You would wind up with an army so cute it couldn't be attacked.

Raj: Well, to paraphrase Shakespeare: It's better to have loved and lost than to stay home every night and download increasingly shameful pornography.
Penny: Oh... you poor baby.
Raj: What's wrong with me, Penny?
Penny: Nothing, nothing. You know, if we weren't friends - and you hadn't brought up that creepy pornography story - I'd be on you like the speed of light squared on matter to make energy.
Raj: Hey, you totally got that right. E = MC squared.
Penny: I listen. I have no idea what it means, but I listen.