Sam: So, now ah, what's the deal with all this TV crap?
Castiel: Pardon me?
Dean: Yeah, amen Padaleski.
Sam: Padalecki.,
Dean: What?
Sam: -Lecki, I'm pretty sure.

Sam: I brought this on.
Bobby: You're damn right you didn't listen. You were reckless and selfish and arrogant.
Sam: I'm sorry.
Bobby: Oh, yeah? You're sorry you started Armageddon? This kind of thing don't get forgiven, boy. If, by some miracle we pull this off... I want you to lose my number.

Sam: We landed in some dimension where you're called Jensen Ackles and I'm something called a Jared Padalecki.
Dean: So, what? Now you're Polish?

Dean: Be my valentine?
Sam: Dude, we're working. Put it back.
Dean: Have a heart.

Wow. I must be the star of this thing.

Dean: Great! More books.
Sam: You love books.

Dean: What's the last ingredient of this spell we're never going to find?
Sam: Blood of a most holy man.

Sam: Wait. That anatomy dummy you were molesting at the lab.
Dean: Excuse me?
Sam: What if that's what this is about?
Dean: What exactly are you accusing me of?

Sam: Cass, you know why you can't go with us, right?
Castiel: My angelic presence will be sensed by Michael thereby nullifying our hopes of a sneak attack.
Sam: Yeah, sorry.
Castiel: And you need me to stay here to babysit Nick and Jack.
Sam: It's not babysitting, Cass.
Castiel: Only in the sense that their both not infants but they both need to be supervised. Jack is lost without his grace and Nick is...he's just a mess.

Dean: Everything is not fine.
Sam: Yeah. My first clue was the flying chainsaw.

See, I told you this was stupid.

Dean: Who, whoa, whoa, wait? You two know each other?
Crowley: Not in the biblical sense, more of a business relationship I'd say.
Sam: [to Samuel] You're Crowley's bitch.

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean