Erica: Promise not to hit on me?
Mark: I can't promise that.
Callie: He can't promise that.

I think it's better to have someone, even if it hurts, even if it is the most painful thing you have done, even if it's the most painful thing you've ever had to do. I think it's better to have someone.

Meredith

Meredith: Hey, you guys....
Izzie: You can't call dibs on a human being.
Meredith: You guys, I think we should move.
Cristina: Let go of the gurney.
Izzie: YOU let go.
Meredith: Move!!!

Someone will be here soon to save the master race from extinction.

Miranda

Erica: I'm sure whatever you're talking about is endlessly exciting, but I kind of had my mind set on saving a life today.
Alex: Sorry.

Richard: Stan, you're a hero, man. You saved Ray's life.
Ray: Stan? Stan? Stan? Damn it, Stan! Stan!

Nick: So, uh, you want to help me plot my revenge?
Lexie: Girlfriend?
Nick: Mmm. Here's what I'm thinking. I page her here, and then, uhh, you know, I'm all like, "I'm dying and I just need to gaze at your beauty one last time," and then she gets here, and I flash her the artery.
Lexie: It's mean.
Nick: Right?
Lexie: I like it.

Nick: Well,you want me to help you plot your revenge?
Lexie: Okay.
Nick: Okay. Here's what I'm thinking. You go out with me. Just like that. Bam! New boyfriend. And he'll be all "what's he got that I don't have?" And you'll be all "carotid artery exposed... Top that, loser," and he'll be all "I can't, I can't top that, I am a loser!"

Nick: You seeing anyone? I... I’m just making conversation. My... my artery is exposed and it kinda limits my game.
Lexie: Okay. Yes... kind of... I am.
Nick: Nice guy?
Lexie: Yeah. He is. Well, he is kinda nice guy disguised as a jerk.
Nick: Oh yeah, I... I know that type. My... my girlfriend was a nice girl disguised as a vapid narcissist. But then it turned out she really she really was just a vapid narcissist.
Lexie: Ouch!

Derek: (to George): What's going on with you and Stevens? Just because I don't sleep in your house anymore doesn't mean I don't hear the gossip.

Nick: How am I doing?
Lexie: Strong and stable.
Nick: Strong and stable? Two words that have never been used to describe me. Ever.

I'm so sick of Meredith and Cristina and their stupid love affair with each other that they have to rub in everyone's faces.

Izzie

Grey's Anatomy Season 4 Quotes

I tell you that I love you, and not one word? For 17 days? Where have you been?

Izzie

[narrating] In the practice of medicine, change is inevitable. New surgical techniques are created, procedures are updated, levels of expertise increase. Innovation is everything, nothing remains the same for long. We either adapt to change, or ... we get left behind.

Meredith