Dean: God?
Castiel: Yes.
Dean: God?
Castiel: Yes. He isn't in Heaven. He has to be somewhere.
Dean: Try New Mexico. I hear he's on a tortilla.
Castiel: No, he's not on any flatbread.

Dean: And the Enochian exorcism?
Castiel: Fake. It actually means, "You, um, breed with the mouth of a goat." It's funnier in Enochian.

These aren't vampires, man. These are douche bags.

Dean

Remember when Crowley kept going on about hating "Dick?" I thought he was just being general.

Dean

If you walk out that door, don't you ever come back.

Dean

Dean: You had sex with April? Did you have protection?
Castiel: I had my angel blade.

Good morning, Vietnam!

Lucifer

Perfect. It's in the middle of the Death Star.

Dean

I'm not wearing any makeup. Oh crap. I'm a painted whore.

Dean

Dean: Until we get you back on your soul train, I'll be your conscience.
Sam: So you're saying you'll be my Jiminy Cricket.
Dean: Shut up. But yeah you fricken puppet, that's exactly what I'm saying.

Cas, stop smelling the dead guy.

Dean

What part of "I don't know" escapes your understanding?

Castiel

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean