With all due respect, Simmons, I don't think you can handle my rod.

Crowley

Chuck, you dick.

Dean

Which one of us is really the monster?

Dean

Sam: Wait. That anatomy dummy you were molesting at the lab.
Dean: Excuse me?
Sam: What if that's what this is about?
Dean: What exactly are you accusing me of?

Dean: Adam doesn't have to be cursed.
Sam: He's a Winchester. He's already cursed.

Sam: What language is it in?
Bobby: Da Vinci Code.

Boys, aim for the head.

Sheriff

I like dogs.

Dean

Crap. She literally meant crap.

Dean

Dean: It frustrates me when you say such reckless things.
Sam: Well, it frustrates me when you'd rather hide than fight.

Dr. Cartwright: Why you?
Dean: Why me what?
Dr. Cartwright: Why do you have to hunt monsters? Why not let someone else do it?
Dean: I can't find anybody else that dumb.

I don’t sweat under any circumstances.

Castiel

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean