Sam, you saved the world.

Sully

That’s what this boils down to, you can’t stand the thought of being alone. I’ll give you this much, you are certainly willing to do the sacrifice, as long as you’re not the one being hurt.

Sam

Actually, I'm lactose intolerant.

Sam

Sam: Okay, last words?
Dean: I think I'm good.
Sam: Yeah, me too.
Dean: Here goes nothing.

Lucifer: Castiel, right? Castiel. I'm told you came here in an automobile.
Castiel: Yes.
Lucifer: What was that like?
Castiel: Um, slow. Confining.
Lucifer: What a peculiar thing you are.

Sam: I brought this on.
Bobby: You're damn right you didn't listen. You were reckless and selfish and arrogant.
Sam: I'm sorry.
Bobby: Oh, yeah? You're sorry you started Armageddon? This kind of thing don't get forgiven, boy. If, by some miracle we pull this off... I want you to lose my number.

Dean: Okay, and why exactly would you want the Devil dead?
Crowley: It's called survival. But I forgot you two are at best functioning morons.
Dean: You're a functioning... morons... moron.

Everything is in here, I mean everything, from the racist truck to me having sex. I'm full frontal in here, dude.

Dean

Woman: I'm sitting like this so you'll look at my breasts. I just bought them. I need a lot of attention.
Dean: Good luck with that.

Oh god. Is that a molar? Do I have a molar in my hair. This has been a really stressful day.

Chuck

So what does the future hold for Sam and Dean? Well, uh, how do you feel about angels? Yeah. you know, because let me tell you, they're not nearly as lame as you think.

Chuck

Dean: Well, you sure look lovely tonight. Especially for a dead chick.
Latisha Actress: Buddy, I have heard that line 17 times tonight, okay? And all from dudes wearing MacGyver jackets. But you seem different.
Dean: How so?
Latisha Actress: Well, you don't seem scared of women.

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean