Dean: Smell that?
Sam: Dude, you're gross.

Dean: Dude, he's short.
Sam: Hey, Gandhi was a great man.
Dean: For a Smurf.

Sam: Oh, hey, Chuck, look. If you really want to publish more books, I guess that's okay with us.
Chuck: Wow. Really?
Sam: No, not really. We have guns and we will find you.

He moves more dirt than the Drudge report.

Dean

Crowley: Together again.
Castiel: Yay.

Cathy Randolph: I could have sworn I saw... the Incredible Hulk.
Sam: The Incredible Hulk?
Cathy Randolph: I told you, it's crazy.
Dean: Bana or Norton?
Cathy Randolph: Oh, no, those movies were terrible. The TV Hulk.
Dean: Lou Ferrigno?
Cathy Randolph: Yes.

I sure hope we don't get Brandon's section.

Bobby

[putting finger with alcohol in baby's mouth] It's good, isn't it?

Dean

I'm a Winchester. I hunt monsters.

Sam

You're saying we should move crap with the power of zen?

Bobby

Sam: Dude, what the hell?
Dean: I had a hunch I went with it.
Sam: You risked my ass on a hunch?
Dean: You're fine. Besides now we know who's turning this town into Willy Wonka's worst nightmare.

Sam: Thank you. Really. Thank you. I won't let you down.
Dean: Oh, I know it. I mean, you are the second-best hunter on the planet

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean