Castiel: What's honorable about a miniature bar in a motel room?
Dean: Everything.

You know, there are about a thousand more polite ways you could say that. I’ll give you a pass on account of the whole ‘raised by monsters’ thing.

Jody

Killing things that need killing is kind of our job. Last I checked, taking pleasure in that is not a crime.

Dean

Sam: Nice work back there. "Look at me, Bitch!"?
Dean: Well, hey, you got another snappy one-liner, I'm all ears.

The guy still has nightmares about the barn episode of The Walking Dead.

Jody

Vamps that kidnap kids? Well, I’m going to enjoy putting you down.

Dean

Sal: Hello, Julian. I'm not looking for trouble. I just want a drink.
Julian: And I want to eat Taylor Swift's heart, but we can't always get what we want.

Look, just cause you’re hot for Metatron or Bieber or Beckham, just cause you know everything about them doesn’t mean that you actually know them.

Dean

All right, look, my name is Sam Winchester. That's my brother Dean. We kill vampires. And werewolves, and demons and basically, we chase down evil and we cut its head off.

Sam

Dean: All right, you're with me, Romeo.
David: Sound good, Buffy.

You betrayed me? No one in the history of torture's been tortured with torture like the torture you'll be tortured with.

Crowley

What is this, "The Godfather" with fangs?

Dean

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean