Sam: So, now ah, what's the deal with all this TV crap?
Castiel: Pardon me?
Dean: Yeah, amen Padaleski.
Sam: Padalecki.,
Dean: What?
Sam: -Lecki, I'm pretty sure.

Dean: Seriously. Why? Why would anybody want to watch our lives?
Sam: Well, according to the interviewer, not very many people do.

What kind of douchebag names a character after himself?

Dean

It appears that Jared and Jensen were seen beating an extra to death.

Bob Singer

Genevieve: You've never even been to our house.
Dean: Well, now that I know there's an alpaca outback, I'm definitely coming back.
Genevieve: Well, alpacas are the greenest animal.

You married fake Ruby?

Dean

Sam: What am I? Dracula?
Dean: George Hamilton Dracula.

Wow. I must be the star of this thing.

Sam

Dude, we're not even in America.

Dean

Look at these male model sons of bitches. Nice "Blue Steel," Sam.

Dean

You guys really punked me. I'm totally gonna tweet this one. "Hola mishamigos. J2 got me good. Really starting to feel like one of the guys."

Misha Collins

Misha? Jensen? What's up with the names around here?

Dean

Supernatural Season 6 Quotes

Just because you're blood doesn't mean you're family. You have to earn it.

Dean

How do you keep your lawn so green? C'mon Dean, you've never been what I call, Brady.

Yellow-Eyed Demon