My Spidey senses are tingling.

Dean

[to Sam] My god, son. You're about as cold as they come.

Samuel

Dean: And how would you characterize their relationship?
Girl: Relationship? No, no, they weren't having a relationship.
Dean: Just the tone or the nature of their conversation.
Girl: Well... loud. And athletic?

Dean: So he came by here?
Girl: Oh, he came by a few times.
Dean: Did he? To uh speak to Nicole?
Girl: Right.

Dean: One of Dad's rules? You never use the same crapper twice.
Sam: Everyone uses the same crapper twice.
Dean: Not us. You know what I mean.

What was that? I think she just cougar-eyed you.

Dean

I'm going to go hit the poop deck.

Dean

Whoa, this one's got a little bit of a wild side. It's all in the eyes, Sam. See it?

Dean

Samuel: You think there are maybe calmer ways we could have done all that?
Sam: Do we care?

I'm sending death a damn fruit basket!

Dean

What was I suppose to do? Let T-1000 walk around and hope that he doesn't open fire?

Dean

I think it just goes to show that being easy is pretty much all upside.

Dean

Supernatural Season 6 Quotes

Sam: Huh.
Dean: Shut it.
Sam: I just said huh.
Dean: I just said shut it.

If the old man's Kermit, whose hand's up his ass?

Dean