Nathan Fillion: How about a guy who looks like Nathan Fillion, but a little more annoyed than Nathan Fillion usually is?
Leonard: What do you think?
Raj: Aww. That's good enough for Facebook.

Penny: I don't want five dollars. I want my dignity.
Amy: So what are we talking about? Ten bucks?

Oh, hey! Did you see that? I figured out how to open my door all by myself. Maybe I'll fling some feces around my cage to celebrate.

Penny

Nathan Fillion: Oh, umm. I think you made a mistake. I'm not an actor.
Raj: Don't say that. You're not Dame Judi Dench but you're pretty great.

Raj: The guy who plays Jon Snow was a jerk and we still watch Game of Thrones.
Leonard: He was a jerk because you rear-ended him.
Raj: I was distracted. It's weird seeing a member of the Night's Watch with kayak strapped to his car.

Are you folding that like a crazy person to get me to do it?

Sheldon

Sheldon: Gee, Penny. Life's given me lemons, what should I do?
Penny: You could shove them somewhere.
Sheldon: Okay, now you're getting creative.

Sheldon: How many Edisons does it take to screw in a light bulb?
Amy: How many?
Sheldon: Who cares he stole the idea and doesn't deserve his own joke.

Amy: Okay, that's enough.
Penny: What? No! I really want to know what happens-- and Bernadette really, really, really wants to know what happens.

Penny reading Amy's book: "Amelia stood before the newly repaired time machine.She regretted giving Cooper the part he needed."
Bernadette: Because she wanted him to give her the part she needed.

Leonard: Stephen Hawking liked our paper. Said the premise is intriguing.
Sheldon: Good to see you again, Mr. Stephen-Hawking- Liked-Our-Paper.
Leonard: And you as well, Mr. Our-Premise-Is-Intriguing.
Howard: How do you do, Mr. I'll- Admit-That's-Pretty-Cool?
Raj: Yeah, you keep setting me up for failure.

Sheldon: Professor Hawking?
Professor Hawking: Oh, brother, you should see the look on your faces.
Leonard: You really didn't like our paper?
Professor Hawking: I like your paper very much. The premise is intriguing.
Sheldon: Then why are you attacking us?
Professor Hawking: If you were sitting in a chair for 40 years, you'd get bored, too. Anyway, got to go. I promised to help the neighbor kid with his math homework. Ciao.

TBBT Quotes

(Singing) Thor and Dr Jones, Thor and Dr. Jones. One plays with lightening, the other plays with bones.

Howard and Raj

I just gave you my virginity, woman. Cool your jets!

Sheldon