Howard: You reported me to human resources?
Sheldon: You violated the sanctity of my mouth.
Howard: Well, I dropped your class, so I hope you're happy.

Sheldon: What are you doing now?
Howard: Making a straw.
Sheldon: Why?
Howard: So I can shoot you with a spitball.
Sheldon: You're not going to do that, and I'll tell you why. This is an institution of higher learning, I am your professor, and you're going to treat me with the prop... You shot your spit in my mouth!
Howard: Is that gonna be on the test? Because I don't think I could do that again.

Sheldon: What are you doing?
Howard: If you're gonna be a crappy teacher, then I'm gonna be a crappy student.

I can't believe I have to waste my time babysitting a bunch of grad students who probably think dark matter is what's in their diapers.

Sheldon

Something just didn't seem right about Koothrapeeney.

Raj

I'm saying, in the spirit of science, what is that little skank's problem?

Amy

Amy: I'm stimulating the pleasures of this starfish. I just need to turn it off.
Penny: What happens if you don't?
Amy: Then I have to sit through lunch knowing this starfish is having a better day than I am.

Sheldon: So your solution is to promote me and pay me more money so tha tI can impart my knowledge to the next generation of scientists?
Mrs. Davis: Yes.
Sheldon: You people are sick.

Sheldon: I recently read that during World War Two, Joseph Stalin had a research program to create supersoldiers by having women impregnated by gorillas.
Howard: What a sick use of science.
Raj: Hey, as long as the baby's healthy.
Amy: I wonder if Stalin considered any other animals.
Leonard: Hippos are the deadliest creature. A half-human, half-hippo soldier would be pretty badass.
Howard: Yes, but when they're hungry-hungry, you can stop them with marbles.
Sheldon: Yeah, the correct animal for interspecies supersolider is koala. You would wind up with an army so cute it couldn't be attacked.

As soon as we get home, I want to have coitus with Amy. Okay, she can't hear.

Sheldon

Be right there, Deb Deb!

Stuart

Bernadette: Why don't I get you a job at the Sitting Around All Day Wearing Yoga Pants Factory?
Penny: They're comfortable.

TBBT Quotes

Penny, there's only one cookie with something in the middle that solves life's problems, and that's an Oreo. Or a Nutter Butter, if you're in a pinch.

Sheldon

Penny: Here's a question-- as an alien pretending to be human, are you planning to engage in any post-prom mating rituals with Amy?
Sheldon: There are post-prom mating rituals?
Penny: Not always. Unless your date drives a van with an air mattress, then always.
Sheldon: Well, if it's part of the prom experience, then I'm open to it.
Penny: You're kidding.
Sheldon: I may be an alien, but I have urges.If Amy wants to copulate by firing her eggs into space, well, then, I will happily catch them with the reproductive sac on my upper flermin. I'm not the best at reading facial cues, but I can see that you're a little turned on.