Sheldon: I'll give you three guesses why I'm so irritated.
Howard: Something happened different from the way you wanted it.
Sheldon: I guess news travels fast.

Sheldon: Is that the attitude to helped you get Penny?
Leonard: No, but I don't have three years to make that gate feel sorry for me.

Bernadette: Leonard makes you watch that [Game of Thrones] too?
Penny: No, no. I like that show. It's got dragons and people doing it.

Sheldon: Play that funky music, white boy!
Leonard: I'm surprised you know that reference.
Sheldon: What reference?

Sheldon: Would you like to play a physics car game I invented called "I Can't Spy"? It's all the nail biting tension of "I Spy," but the added fun of sub-atomic particles and waves outside the visible spectrum.
Leonard: If it's half as much fun as "One Times Ten to the Fourth Bottles of Beer on the Wall," I'm in.

We won't know if there's equality until female Thor has a baby, and the avengers are cool with her pumping breast milk at work.

Amy

Bernadette: Did she throw anything away?
Howard: Nope. If I find my foreskin, I'm gonna kill myself.

Oh, please. I have ideas all day long. Reverse Sea World, where dolphins are allowed to pet people. A new clothing size in between medium and large, called "marge." Snow White retold from the point of view of Sneezy. Why won't Doc prescribe him something? We finally find out.

Sheldon

Penny: I mean, who even reads Scientific American.
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Okay, then, how about this. Let's invite everyone over to dinner. It'll be like Ma's feeding us one last time.

Howard

While my brother was getting an STD, I was getting a PhD.

Sheldon

Leonard: And we weren't even watching TV! We were watching Netflix like the kids do!
Penny: Yeah! Is it a comedy? Is it a drama? Nobody knows!

TBBT Quotes

I just gave you my virginity, woman. Cool your jets!

Sheldon

(Singing) Thor and Dr Jones, Thor and Dr. Jones. One plays with lightening, the other plays with bones.

Howard and Raj