Penny: See, this is why I've been saying we should keep champagne on ice.
Sheldon: Sarcasm?
Amy: Yes.
Sheldon: That was tricky because when it comes to alcohol she generally means business.

Amy: After a careful evaluation of our relationship. We decided that the time was right to take a step forward.
Leonard: Okay.
Sheldon: Do you want to say it?
Amy: Let's say it together!
Sheldon and Amy: We're getting a turtle!

Excuse me. You better find my husband's mother, because one way or another, we're walking out of here with a dead woman!

Bernadette

Sheldon: If you could wake up tomorrow having gained any one quality or ability, what would it be?
Penny: Well, not to steal from the Bible, but turning water into wine sounds pretty good.

Leonard: I'm telling you, you can't create love in a few hours. Right?
Penny: Careful. You're poking at the whole foundation of The Bachelor.

Amy: I just read about an experiment designed to see if you can make two people fall in love in a matter of hours.
Leonard: That doesn't sound right. My research has shown that it takes three to five years of shameless begging.

Let's have a toast. To Mrs. Wolowitz. A loving mother ... to all of us. We'll miss you.

Leonard

Sheldon: I didn't care for her yelling, but now that I'm not going to hear it again, I'm sad.
Leonard: If you want, I can yell at you later.
Sheldon: It won't be as good.

Sheldon: When I lost my father, I didn't have any friends to help me through it. You do.
Penny: I really thought he was going to say, "Let it go."

No. My mom died.

Howard

Nathan Fillion: How about a guy who looks like Nathan Fillion, but a little more annoyed than Nathan Fillion usually is?
Leonard: What do you think?
Raj: Aww. That's good enough for Facebook.

Penny: I don't want five dollars. I want my dignity.
Amy: So what are we talking about? Ten bucks?

TBBT Quotes

Sheldon: I recently read that during World War Two, Joseph Stalin had a research program to create supersoldiers by having women impregnated by gorillas.
Howard: What a sick use of science.
Raj: Hey, as long as the baby's healthy.
Amy: I wonder if Stalin considered any other animals.
Leonard: Hippos are the deadliest creature. A half-human, half-hippo soldier would be pretty badass.
Howard: Yes, but when they're hungry-hungry, you can stop them with marbles.
Sheldon: Yeah, the correct animal for interspecies supersolider is koala. You would wind up with an army so cute it couldn't be attacked.

Raj: Well, to paraphrase Shakespeare: It's better to have loved and lost than to stay home every night and download increasingly shameful pornography.
Penny: Oh... you poor baby.
Raj: What's wrong with me, Penny?
Penny: Nothing, nothing. You know, if we weren't friends - and you hadn't brought up that creepy pornography story - I'd be on you like the speed of light squared on matter to make energy.
Raj: Hey, you totally got that right. E = MC squared.
Penny: I listen. I have no idea what it means, but I listen.