Amy: The meme has reached full penetration.
Sheldon: Pun intended?
Amy: No. Happy accident.

Amy: I should let you know that she asked for details about our dalliance.
Sheldon: Interesting. So it went beyond the mere fact of coitus to a "blow by blow" as it were.
Amy: Pun intended?
Sheldon: I'm sorry. What pun?

Penny: Do you want some coffee liqueur on your ice cream?
Amy: Ah, here's the alcohol and drug peer pressure mother warned me about. I was starting to think it was never going to happen! Yes, please!

Today's the day a girl's finally going to touch you in your little special place.

Penny

Look, if you want your relationship with Leonard to continue you're going to have to believe whatever wild-eyed cockamamie excuse the white devil has the nerve to offer you.

Raj [to Priya on the phone]

Leonard: Oh, geez, I - I don't know if I can ditch Priya two nights in a row.
Raj: Oh, come on, man. Bros before... my sister.

You know, for the first couple of months, whenever I would take off my bra, he would giggle and say 'oh, boy, my breast friends!'

Penny [referring to Leonard]

He was robbed of a bunch of imaginary crap that's useful in a make-believe place.

Penny [referring to Sheldon]

Three thousand hours, three thousand hours clicking on that mouse, collecting weapons and gold. It's almost as if it was a huge waste of time.

Sheldon

Leonard: You called the police because someone hacked your World of Warcraft account?
Sheldon: What choice did I have? The mighty Sheldor, level 85 blood elf, hero of the Eastern kingdoms has been picked clean, like a carcass in the desert sun. Plus, the FBI hung up on me.

Believe in magic, you Muggle!

Wolowitz

If I had contacts I would have been the coolest Debate Club president to be shoved in his own cello case.

Leonard

The Big Bang Theory Season 4 Quotes

You have broad hips and a certain corn-fed vigor. Is your womb available for rental?

Sheldon

At best, it's a modest leap forward from the technology that gave us Country Bear Jamboree.

Sheldon