Jess: The only anti-depressant you need is in my pants!
Guy: It's really a medical issue.

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A depressant, or central depressant, is a drug or endogenous compound that lowers or depresses arousal levels and reduces excitability.Depressants are also occasionally referred to as "downers" as they lower the level of arousal when taken. Stimulants or "uppers" increase mental and/or physical function are the functional opposites of depressants.

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New Girl Season 2 Episode 23 Quotes

Cece: I thought I threw that thing out the window.
Schmidt: That only made it stronger.

I'm going on a date with Elizabeth tonight. I haven't had sex with her since I was fat and accessing my penis was like getting a remote control out of the couch.