As part of a class assignment, Drew discovers that Cole has a potentially cancerous mole and the tests come back showing it is malignant.  Cole has to get an operation and Lucy tells him she'll gather his friends to be there for him after the surgery.  However, when no one shows up, Cole is hurt and takes it out on Lucy, who ditches him, leaving him alone.

Meanwhile, Kelso goes in for a routine set of tests for Dr. Cox and finds out he's no longer able to drive and becomes dependent on the students and other teachers to drive him to work. Kelso ends up giving Cole some advice on telling his friends how he really feels, so even when he's a jerk they'll still be there for him when he needs them. In the end, Cole buys everyone a pizza and seems to be growing as a human being, while Kelso hops back behind the wheel and nearly drives everyone over.

Dr. Cox and Denise, meanwhile, go through a power struggle over the interns including Trang and Cole.  In the end, Cole can't handle being stuck between his girlfriend and mentor, so he gets the two of them together and makes them talk.