When Peter goes back in time and messes things up with Lois, she ends up marrying Quagmire and having a Chris, Meg and Stewie that look like Quagmire instead.
Peter and Lois spend the entire day in bed on Valentine's day on Family Guy. "Valentine's Day in Quahog" is the 13th episode of the show's 11th season.
Aunt Margarite [on her video will]: Lois, you were always my favorite niece; I just knew you would find a wonderful man who would make all your dreams come true. But I was wrong. Peter: And now you're dead. Score one for Peter