Jake [about Joanie]: That girl's really annoying.
Alan: I think maybe she has a crush on you.
Jake: Well, yeah! That's what's annoying.
Alan: You don't really like girls yet huh?
Jake: No, I like girls, I'm just not into eight-year-olds

Alan: So...Frankie, why didn't you tell us you had a daughter?
Frankie: Ok guys, here's the deal. I didn't want you to know

Alan: It was like our souls were merging.
Charlie: That was saliva, Alan

Alan: If Mom's ever in a coma you're the one who has to decide whether to pull the plug.
Charlie: Pull

Last summer he actually fractured his ass doing a cannonball into the bath tub

Berta: Wait a minute. Isn't she the one who dumped you?
Alan: Someone dumped Charlie?!?!
Berta: Broke his little black heart. It was pathetic!

Judith: Oh, come on, Charlie. You know there was always sexual tension between us.
Charlie: Really? I thought it was just regular tension.
Judith: I saw you looking at my chest.
Alan: You looked at my ex-wife's chest??
Charlie: Hey, I'm a guy

Alan: Judith's sister is hitting on me.
Charlie: She's not hitting on you, she's hitting on her sister's ex-husband.
Alan: But that's me!

Alan: Charlie, please don't make a bad situation worse. Judith and Liz have been at each other's throats for years.
Charlie: Why's that?
Alan: I don't know. Maybe it is because Liz was always more popular, maybe because Judith was smarter, maybe, and this is just a theory on my part, it had something to do with the fact that Liz did my brother in the coatroom at our wedding reception.
Charlie: Well, it is no secret why she was popular.
Alan: At our wedding reception, Charlie. In the coatroom. You where louder then the band!
Charlie: You make it sound so sleazy.
Alan: I'm sorry. Class it up for me.
Charlie: Okay, to begin with, we were on a mink coat...
Alan: Goodbye!

Jake [referring to his mom and Aunt]: Why are they fighting?
Alan: Oh, they're not fighting, they're discussing.
Jake: I'm a child of divorce, Dad. I know the difference.

Berta [trying to convince Alan Jake is constipated]: I'm telling you, my youngest once ate a whole can of Play-Doh—stopped her up for two weeks!
Alan: All right, Berta.
Berta: She finally pooped out a whole ashtray.
Alan: Berta!
Berta: That was the day I quit smoking

Alan: You have someone who comes into your house and glues your cabinets shut regularly?
Charlie: You've met some of the whack jobs I've went out with, this shouldn't be that much of a stretch

Two and a Half Men Quotes

Jake: Can I go back to mom's tomorrow?
Alan: Why?
Jake: I want to hang out with my friends.
Alan: What, all of a sudden your father's not good enough for you?
Jake: It's not "all of a sudden."

Alan: Since when do you have a wet suit?
Charlie: Since I moved to the beach and noticed it was full of hot surfer chicks. If I lived next to Jellystone Park I'd have a bear suit and a picnic basket