Fitz: Treat this mole like a cancer.
May: I'll cut it out myself

This reality may be upside down, but Fitz is still Fitz. He's a good person.

Simmons [to Daisy]

It's me again. Phil Coulson. I called Hydra on you. My bad.

Coulson [to Simmons]

Coulson: Got to say, the whole Rebel Alliance aesthetic is really working for me.
Mace: I'll take that as a compliment. I think.

Trust is a luxury these days.

Mace

Simmons: You're not crazy!
Coulson: I live alone and make my own soap.
Simmons: It's quaint. Hipster, even!

I am fresh out of sympathy for liars who kidnapped my friends and replaced them with killer robots.

Simmons [to Radcliffe]

What is it about that guy? Every time I see him, I get this weird itch. Like hives?

Coulson [to Simmons, about Ward]

Daisy: Why are you doing this, Fitz?
Fitz: It's Doctor Fitz.

If anyone could get you to wake up and realize this world isn't real, it's her. She loves you, and you love her.

Daisy [to Fitz]

Madame Hydra: I'm just trying to give people what they want. Why is that wrong?
Daisy: Because sometimes what people want isn't right for them.

Bee-tee-dubs, your psycho-prison sucks.

Daisy [to Madame Hydra]

Agents of S.H.I.E.L.D. Quotes

Kasius: Yo-Yo Rodriguez? How peculiar.
Yo-Yo: Says the space mime!

Sousa: Hey, what are you doing up?
Daisy: Why do you care?
Sousa: Because you don't.