He would never give up on Talbot! And he would never see him as a maniac! He would see him as a man, a broken *man*! Coulson’s the only one who could talk him through this, that’s what he does!

Daisy [about Coulson]

Yo-Yo: You’re going to die.
Mack: Well. Everyone dies. And on that day, we’ll have to answer up there for what we’ve done down here.
Yo-Yo: It’s not God I’m afraid of.

Yo-Yo: I heard you were up.
Coulson: ‘Up’ would imply the ability to stand. I’m not there yet.

Deke: Navigating the past happens to be my specialty.
Yo-Yo: Last time you got stupid drunk and ended up in jail.
Deke: That's not true. I was pleasantly drunk and it was hilarious.
Daisy: He'll be fine. It's prohibition, so alcohol is illegal anyway.
Deke: It's what? Who would think that's a good idea? Even the Kree let us make our own boot juice.

Two years in ten seconds. It's like the worst episode of "This Is Your Life" ever.

Coulson

Coulson: It's the Great Depression. A decade before Pearl Harbor. Almost four decades before Apollo 11. These people have never even seen a TV.
Mack: Or a black man in a fine suit apparently.
Daisy: Imagine if they saw my powers.
Coulson: Or my gears. Do I have gears, do you think?

Simmons: Fitz said he tried to send me a message, but I'm not entirely sure how to find it.
Yo-Yo: You must be worried about him.
Simmons: He's safe. But I do miss him.
Yo-Yo: Well, it's not exactly your first go at being separated by space and time.
Simmons: Practice makes perfect I suppose.

Mack: If they're Chronicoms, they're waiting for FDR.
Coulson: When he gets here, it'll be a whole new deal. Am I right?

Freddy: Faster! They're gaining on us!
Mack: This boat won't go any faster!
Freddy: You gotta give them the slip!
Deke: Yeah, and we gotta lose them too.

I'm a doctor, not a dame.

Simmons

May: You're not Sarge.
Coulson: No, I'm not.
May: You're not Coulson either.
Coulson: Well, yes and no. Aren't you at all surprised? I mean, I was dead.
May: You still are.

Simmons: The compound is part of a formula that first appeared in Germany during World War II.
Ernest: During World War II? I think you're half-cocked on the moonshine.
Simmons: It was synthesized by a German scientist named Abraham Erskine.
Coulson: I don't like where this is going.
Simmons: And first used by a man named Johann Schmidt.
Daisy: The Red Skull.
Simmons: Freddy Malick is about to deliver the key ingredient used to create the Super Soldier serum.
Ernest: You give a name like that to your juice, it better have a hell of a kick.
Coulson: You have no idea.

Agents of S.H.I.E.L.D. Quotes

Kasius: Yo-Yo Rodriguez? How peculiar.
Yo-Yo: Says the space mime!

Sousa: Hey, what are you doing up?
Daisy: Why do you care?
Sousa: Because you don't.