Stewie: Alright Brian, I'm gonna go up to the upper level and run this wire down through the wall. Grab your walkie, I'll call you when I get up there.
Brian: Okay.
(Stewie walks away, is heard over the walkie-talkie)
Stewie: Brian, pick up. Over.
Brian: What?
Stewie: Brian, please say "over" when you are finished talking. Over.
Brian: (sighs) What? Over.
Stewie: Do you see the wire yet? Over.
Brian: No.
Stewie: Nooooo what? Over.
Brian: No. Over.
Stewie: Okay, I'm gonna start feeding it through. Over.
Brian: Wait, If you haven't started feeding it, why'd ya ask me if I could see it?
Stewie: Didn't copy that. Over.
Brian: I said why did ya ask me if I could see it if you haven't started feeding it. Over.
Stewie: Oh that's better, I can hear you now. Over. Do you see it yet? Over.
Brian: You know, you're a jackass. For the record, I don't wanna hang out with you anymore when this is over.
Stewie: When this is what Brian? Over.
Brian: I said, I don't wanna hang out with you anymore when this is over.
Stewie: When this is what? You've got to finish your sentence. Over.
Brian: That's it, my sentence is over.
Stewie: Your sentence is what, Brian? Over.
Brian: My sentence is- wait a minute. I have to say over, even if the sentence ends with the word over?
Stewie: Ends with the word what, Brian? Over.
(the wire descends through the wall)
Brian: Oh, I see the wire.
Stewie: You see the wire what? Over.
Brian: Over! (yanks on the wire, pulling Stewie down with it)

Lois: Wow Peter, I gotta say, you've really been true to your word about treating Meg better.
Peter: She's my only daughter, Lois. She needs to be protected, like a rare gemstone, or the herniated scrotum of an older gentleman.

This is disgusting. It smells, it's falling apart, and you can hear the mice humping in the walls.

Brian

Lois: Peter, Meg's been down there an awfully long time.
Peter: Boy, you cannot wait to criticise her at every turn, can you, Lois?

(about Meg's wedding dress) Look at her fat shoulders in those spaghetti straps. It's like bread baking around twine!

Stewie

Stewie: Hey, Brian, knock knock!
Brian: Who's there?
Stewie: (whispering) Two friends, building a house together.

Peter: That's an even more beautiful sight than 72 virgins waiting in heaven for a suicide bomber.
Teenaged boy: Hey, we're just playing some Magic: The Gathering. Wanna join?
Terrorist: OSAMA!

Neil: Hello.
Chris: Hi. Name, please.
Neil: Neil Goldman.
Chris: (checks his list) Goldman, Goldman. Sorry, no Neil Goldman.
Neil: Oh, I beg your pardon. I meant to say Chris Griffin.
Chris: (checks his list) Griffin, Griffin. Oh, here it is. Says you're supposed to be an usher. (hands his list and pen to Neil) Well, you'll need this.
Neil: Name, please.
Chris: Chris Griffin.
Neil: (checks his list) Griffin, Griffin, hmm. I'm sorry, sir, Chris Griffin has already checked in.
Chris: Well, that's impossible!

Lois: Peter, why are you wearing that suit?
Stewie: Yes, you look like the statue of liberty's pimp.
(Stewie and Brian share a High-five)

Carter: What's going on here?
Peter: We're taking what's ours! Actually, we're taking what's yours, but we don't think you deserve it, so we're calling it ours and taking it!

Peter: Alright guys, it's going to be a long night of border patrol, so I brought in Michael McDonald to help us.
Cleveland: How's he gonna help us?
Peter: He's going to do backup vocals for everything we say.
Cleveland: How's he gonna know what we're saying?
Michael McDonald (singing): How's he gonna know what we're saying?
Quagmire: Is he gonna do it for all of us?
Michael McDonald (singing): Is he gonna do it for all of us?
Peter: Yeah I hired him for the night, cost about $250 an hour, so don't skimp on the conversation.
Michael McDonald (singing): Yeah I hired him for the night, cost about $250 an hour, so don't skimp on the conversaaaationnn!
Cleveland: That sounds nice.

Lois: Peter, have you seen Stewie's Speedy Gonzales video? He won't go to sleep without it.
Peter: I threw it away.
Stewie: What?! What the hell man I don't throw away your stuff. And where's my goat?
Lois: Peter, why would you do that?
Peter: Because Speedy Gonzales is an immigrant and a bad influence on our children!

Family Guy Season 6 Quotes

You can kiss the lower part of the back of the canister that is my body!

Cleveland (R2-D2)

Death Star Officer 1: Any attack made by the Rebels against this station would be a useless gesture, no matter what technical data they've obtained. This station is now the ultimate power in the universe.
Stewie (Darth Vader): That is fantastic! Terrific work! So no weaknesses at all, huh?
Death Star Officer 1: N- (considers) no.
Stewie (Darth Vader): You, uh, you hesitated there. Is there something I should know?
Death Star Officer 1: No, it's virtually indestructable, like 99.99 percent.
Stewie (Darth Vader): Uh...OK, wouldn't be doin' my job if I didn't ask what's the .01?
Death Star Officer 1: Well, I- I mean, there's this little hole, it was kind of an aesthetic choice by the architect, and if you shoot a laser into this hole, uh, the station blows up.
Stewie (Darth Vader): Whoa, whoa, whoa, whoa, whoa, that sounds like a pretty big design flaw there.
Death Star Officer 1: No, no, no the hole's only two meters across.
Mayor Adam West (Grand Moff Tarkin): Well, that's no bigger than a womp rat.
Death Star Officer 1: Exactly. And even to get within range of it, you have to skim along this whole trench, it's not a big deal.
Stewie (Darth Vader): Well, I mean, I mean, can't we board it up or, you know, put some plywood over it or something?
Death Star Officer 1: Well, that would look terrible! I mean, we got to think about re-sale.
Stewie (Darth Vader): Re-sale? Wh-what are you talking about? This property is right above Sunset, the value's only gonna go up.
Death Star Officer 1: Lord Vader, your inside references to the Los Angeles real estate market haven't given you the clairvoyance to turn a profit on that condo in Glendale, nor has it-
(Vader begins choking him with the Force)
Stewie (Darth Vader): I find your lack of faith disturbing. That property is in a prime location, twenty minutes to the beach, twenty minutes to downtown!
Death Star Officer 1: (choking) There's nothing to do downtown!
Mayor Adam West (Grand Moff Tarkin): Enough of this! Vader, release him.
Stewie (Darth Vader): As you wish. (releases the officer, who collapses on the table, gasping for air) All right, so we gonna plug up that hole?
Death Star Officer 2: Yeah, we can get it done tomorrow if price is no object.
Stewie (Darth Vader): Eyuuuuh...
Death Star Officer 2: We'll get estimates.
Stewie (Darth Vader): Yeah, get estimates, yeah ha, yeah, yeah ha ha, yeah.