The past 10 years I've taken care of every single Gallagher -- except one. I'm done.

Fiona

I can make sure that we do our drugs and beat each other up indoors -- just like the rest of of you folks.

Frank

My other wife doesn't love how you sold our wife into sex slavery.

Kevin

New Fiona: Bitch.
Frank: You tell them, New Fiona.
Fiona: That's new Fiona?

Frank: God is handing me a do-over. New Ian, new Lip, new Debbie.
New Debbie: I'm a boy.
Frank: You need a haircut, Debs.

Who do I give a BJ to around here to get a meal?

New Fiona

I am just as likely as anyone of this family to make something of myself.

Fiona

Carl: Luthor, what's up?
Luthor: What's up is you gave my daughter gonorrhoea you little shit.

I'd have to care for it to be a Sean rebound thing.

Fiona

Lip: Yo Fi, pickaxe or sledgehammer.
Fiona: Sledgehammer.

Fiona: What time is it?
Veronica: Not as early as you ringing my doorbell last night.

Ian: I confronted Caleb about that chick. He's screwing her.
Lip: I guess there's something to be said for honesty. Right?
Ian: Except, he says he's not cheating.
Lip: How did he come up with that reasoning?
Ian: He says if it were a guy, then he'd be cheating.

Shameless Quotes

The best gift you can give is neglect. Neglect fosters self-reliance.

Frank [to Lip]

We’re all addicts Fiona, trying to fill a void. Some of us are just better at hiding it, right?

Robbie