Newton: Barry Manilow was an underappreciated genius of his time.
LaMarr: Then how come I want to throw myself out of the airlock?
Yaphit: I gotta say, watching your corpse drift away to this music would be so peaceful.

Marcus: Hey! You can't just leave us here.
Isaac: You are small and feeble. I will move at a faster pace alone. The weapon will increase your chances of survival by twenty-four percent.

Isaac: Your commands have little to no effect on their behaviour. Perhaps you should reevaluate your method of controlling them.
Dr. Finn: Just what I need. Parenting tips from a talking hubcap.

Isaac: Where is your counterpart?
Dr. Finn: I don't have a husband.
Isaac: Was he destroyed?
Dr. Finn: No
Isaac: Did you grow to despise each other and terminate your coupling?
Dr. Finn: I chose to be a single mother.

On my planet, when a program is not functioning properly, it is deleted.

Isaac

Isaac: The older, less intelligent one seems to derive pleasure from inflicting damage on his younger, weaker sibling.
Dr. Finn: He's a kid. They act up.

Isaac: Doctor, are your children always this combative?
Dr. Finn: Only when they're awake.

Marcus: Oh Mom, you suck.
Dr. Finn: I'm a mom. It's my job.

Lysella: Everyone deserves a voice. That's what we're taught.
Bortus: A voice should be earned, not given away.

Grayson: We haven't seen evidence of any codified legal framework. It all seems subject to public vote at any given time.
Isaac: Captain, what she is describing is an absolute, unstructured democracy. There is no record of any previously discovered society operating in such a fashion.
Malloy: Government by American Idol.

I will personally order him not to hump things

Mercer

Lysella: What happened to your nose?
Kitan: It's a deviated septum
Grayson: She's a coke addict.

The Orville Quotes

Mercer: I know Gordon has his issues but we all know that there's nobody that can drive a starship like him.
Admiral: Didn't he once draw a penis on the main viewing screen of Outpost T-85?
Mercer: He's drawn a lot of penises on a lot of things.

Mercer: I've had some personal stuff that's been going on... It's not really worth going into... Can I have one of these mints?
Admiral: Those are marbles.